Fear Potentiation and Fear Inhibition in Posttraumatic Stress Disorder

This study is ongoing, but not recruiting participants.
Sponsor:
Information provided by (Responsible Party):
Erica Duncan, MD, Emory University
ClinicalTrials.gov Identifier:
NCT00209040
First received: September 14, 2005
Last updated: September 29, 2014
Last verified: September 2014
  Purpose

The current study will investigate the ability of people with and without fear symptoms after trauma to inhibit fear in an experimental situation.


Condition Intervention
Posttraumatic Stress Disorder
Procedure: acoustic startle testing

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Fear Potentiation and Fear Inhibition in Posttraumatic Stress Disorder

Resource links provided by NLM:


Further study details as provided by Emory University:

Primary Outcome Measures:
  • fear potentiation of acoustic startle [ Time Frame: baseline ] [ Designated as safety issue: No ]
    percent change in acoustic startle magnitude during visual cue conditioned to aversive stimuli, compared to trials without aversive sitmuli


Estimated Enrollment: 250
Study Start Date: January 2001
Estimated Study Completion Date: December 2015
Estimated Primary Completion Date: December 2015 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
1
Subjects with posttraumatic stress disorder
Procedure: acoustic startle testing
See protocol description for methodological details
2
Healthy controls
Procedure: acoustic startle testing
See protocol description for methodological details
3
Combat controls
Procedure: acoustic startle testing
See protocol description for methodological details

  Show Detailed Description

  Eligibility

Ages Eligible for Study:   18 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

see protocol description

Criteria

Inclusion Criteria:

  • Age 18-80
  • Diagnosis of PTSD
  • Healthy controls (no history of PTSD)
  • Combat controls (no history of PTSD)

Exclusion Criteria:

  • No drug or alcohol abuse or dependence
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00209040

Locations
United States, Georgia
Atlanta VA Medical Center
Decatur, Georgia, United States, 30033
Sponsors and Collaborators
Emory University
Investigators
Principal Investigator: Erica Duncan, MD Emory University/Atlanta VA Medical Center
  More Information

No publications provided

Responsible Party: Erica Duncan, MD, Associate Professor, Emory University
ClinicalTrials.gov Identifier: NCT00209040     History of Changes
Other Study ID Numbers: IRB00000983
Study First Received: September 14, 2005
Last Updated: September 29, 2014
Health Authority: United States: Institutional Review Board

Keywords provided by Emory University:
PTSD
Acoustic startle

Additional relevant MeSH terms:
Disease
Stress Disorders, Post-Traumatic
Stress Disorders, Traumatic
Anxiety Disorders
Mental Disorders
Pathologic Processes

ClinicalTrials.gov processed this record on October 23, 2014