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Fear Potentiation and Fear Inhibition in Posttraumatic Stress Disorder

This study is currently recruiting participants.
Verified November 2012 by Emory University
Sponsor:
Information provided by (Responsible Party):
Erica Duncan, MD, Emory University
ClinicalTrials.gov Identifier:
NCT00209040
First received: September 14, 2005
Last updated: November 8, 2012
Last verified: November 2012
History of Changes
  Purpose

The current study will investigate the ability of people with and without fear symptoms after trauma to inhibit fear in an experimental situation.


Condition Intervention
Posttraumatic Stress Disorder
 Procedure: acoustic startle testing

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Fear Potentiation and Fear Inhibition in Posttraumatic Stress Disorder

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Emory University:

Estimated Enrollment: 250
Study Start Date: January 2001
Estimated Study Completion Date: December 2013
Estimated Primary Completion Date: December 2013 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
1
Subjects with posttraumatic stress disorder
 Procedure: acoustic startle testing
See protocol description for methodological details
2
Healthy controls
 Procedure: acoustic startle testing
See protocol description for methodological details
3
Combat controls
 Procedure: acoustic startle testing
See protocol description for methodological details

  Show Detailed Description

  Eligibility

Ages Eligible for Study:   18 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

see protocol description

Criteria

Inclusion Criteria:

  • Age 18-80
  • Diagnosis of PTSD
  • Healthy controls (no history of PTSD)
  • Combat controls (no history of PTSD)

Exclusion Criteria:

  • No drug or alcohol abuse or dependence
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00209040

Contacts
Contact: Wendy Hasenkamp, Ph.D. 404-321-6111 ext 7154 whasenk@gmail.com
Contact: Erica Duncan, MD 404-321-6111 ext 7532 erica.duncan@va.gov

Locations
United States, Georgia
Atlanta VA Medical Center Recruiting
Decatur, Georgia, United States, 30033
Contact: Seth Norrholm, PhD     404-321-6111 ext 5887     seth.norrholm@med.va.gov    
Principal Investigator: Erica Duncan, MD            
Sponsors and Collaborators
Emory University
Investigators
Principal Investigator: Erica Duncan, MD Emory University/Atlanta VA Medical Center
  More Information

No publications provided

Responsible Party: Erica Duncan, MD, Associate Professor, Emory University
ClinicalTrials.gov Identifier: NCT00209040     History of Changes
Other Study ID Numbers: 939-2001
Study First Received: September 14, 2005
Last Updated: November 8, 2012
Health Authority: United States: Institutional Review Board

Keywords provided by Emory University:
PTSD
Acoustic startle

Additional relevant MeSH terms:
Stress Disorders, Post-Traumatic
Stress Disorders, Traumatic
Anxiety Disorders
Mental Disorders

ClinicalTrials.gov processed this record on May 16, 2013