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Airway IgA: Respiratory Tract IgA Levels in Critically Ill Intubated Patients

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
University of Wisconsin, Madison
ClinicalTrials.gov Identifier:
NCT00205309
First received: September 13, 2005
Last updated: October 16, 2012
Last verified: October 2012
History of Changes
  Purpose

This study will examine the impact of acute illness on sequential airway IgA levels in intensive care patients who will require prolonged intubation. Infections are the most common cause of late deaths in non-head injured trauma patients and a frequent cause of morbidity and mortality in hospitalized patients, especially intubated Intensive Care Unit (ICU) patients. Nosocomial pneumonia is the most common of these infections, and its incidence in defined populations of critically injured patients is responsive to route and type of nutrition. This study will focus on the mechanisms of specific immune mucosal defenses in intestinal and extraintestinal sites and link enteral feeding (or lack of it) with maintenance (or deterioration) of respiratory mucosal defenses.


Condition
Intubation
Critically Ill

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Respiratory Tract IgA Levels in Critically Ill Intubated Patients

Further study details as provided by University of Wisconsin, Madison:

Enrollment: 13
Study Start Date: January 2003
Study Completion Date: June 2011
Primary Completion Date: June 2011 (Final data collection date for primary outcome measure)
  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Intubated intensive care patients

Criteria

Inclusion Criteria:

  • Subjects must be intubated, intensive care patients.

Exclusion Criteria:

  • No severe pulmonary contusions or evidence of airway bleeding
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00205309

Locations
United States, Wisconsin
University of Wisconsin Hospital and Clinics
Madison, Wisconsin, United States, 53792
Sponsors and Collaborators
University of Wisconsin, Madison
Investigators
Principal Investigator: Kenneth Kudsk, MD University of Wisconsin Medical School
  More Information

No publications provided

Responsible Party: University of Wisconsin, Madison
ClinicalTrials.gov Identifier: NCT00205309     History of Changes
Other Study ID Numbers: 2002-562
Study First Received: September 13, 2005
Last Updated: October 16, 2012
Health Authority: United States: Institutional Review Board

Keywords provided by University of Wisconsin, Madison:
intubated patients

Additional relevant MeSH terms:
Critical Illness
Disease Attributes
Pathologic Processes

ClinicalTrials.gov processed this record on May 23, 2013