Choline Quantification in Breast Cancer by MRS
Choline has been found in increased concentration in breast cancer patients. Hypothesis: The choline signal as observed by MRS is sensitive to treatment, and a positive response to treatment will give a reduction in choline concentration.
The purpose of this study is to establish methods for quantification of choline in breast cancer by MRS
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Choline Quantification in Breast Cancer by MRS|
|Study Start Date:||November 2007|
|Study Completion Date:||June 2009|
- Establishment of new MRS sequence for choline quantification of choline. This sequence is choline-selective, and signals from water and lipids are suppressed simultaneously.
- Compare to different methods for choline quantification. The first method is quantification through an external phantom standard, containing a known concentration of choline. The other method is based on the utilisation of internal water signal as a reference.
Both calculations can be performed from the same MR exam. Ten patients will be included in the study.