Acute, Affective, Organic Disorders.
The purpose of the study is to investigate whether patients with brief depressive periods together with other fluctuating psychiatric symptoms, have this condition due to epilepsy or an other organic brain disorder.
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Signs of Organic Brain Dysfunction in Psychiatric Patients With Fluctuating Psychiatric Symptoms Including Brief Depressions Compared to Patients With a Major Depressive Episode.|
Ordinary laboratory tests, medication, substances.
|Study Start Date:||October 1998|
|Study Completion Date:||June 2010|
|Primary Completion Date:||October 2004 (Final data collection date for primary outcome measure)|
A limited number of patients admitted to psychiatric acute wards or Psychiatric Intensive Care Units are admitted with a fluctuating array of psychiatric symptoms including brief depressive episodes. These patients do not fit into the present diagnostic systems due to short duration of affective symptoms and the fluctuating arrays of other symptoms. Case histories indicate that these patients have psychiatric conditions due to epilepsy or organic brain dysfunctions.
In the study acutely admitted patients filling criteria for two recent DSM-4 axis 1 diagnoses (one is a brief depressive period) during the last two weeks are compared to age- and sex-matched patients acutely admitted with a major depressive disorder. The patients are rated with a number of rating scales at admittance, day 5, after two weeks and three months. EEG and QEEG are taken three times the first week. MRI, drug screening and blood screening of medication-concentrations are taken.
|Østmarka Psychiatric Department, St. Olavs Hospital|
|Trondheim, Norway, 7441|
|Study Chair:||Olav M Linaker, Professor||Norwegian University of Science and Technology|