Transcranial Magnetic Treatment (TMS) in Unipolar Depression - Full Text View

Sponsor:	St. Joseph's Healthcare Hamilton
Collaborator:	Queen's University, Kingston, Ontario
Information provided by:	St. Joseph's Healthcare Hamilton
ClinicalTrials.gov Identifier:	NCT00186784

Purpose

Repetitive Transcranial Magnetic Stimulation (rTMS) can improve mood and decrease sadness in patients with depression.

In this study, the investigators seek to increase their understanding about how rTMS improves depression, and to determine which form of rTMS is most effective for depression, when used in combination with antidepressant medication.

Condition	Intervention	Phase
Unipolar Depression	Procedure: Transcranial Magnetic Stimulation (TMS)	Phase 0

Study Type:	Interventional
Study Design:	Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Single Group Assignment Masking: Double Blind (Subject, Investigator) Primary Purpose: Treatment
Official Title:	Repetitive Transcranial Magnetic Stimulation (rTMS) in Unipolar Depression

Resource links provided by NLM:

MedlinePlus related topics: Depression

U.S. FDA Resources

Further study details as provided by St. Joseph's Healthcare Hamilton:

Primary Outcome Measures:

Hamilton Depression Rating Scale [ Time Frame: Pre TMS and post TMS ] [ Designated as safety issue: No ]
Beck Depression Rating Scale [ Time Frame: pre TMS and post TMS ] [ Designated as safety issue: No ]

Secondary Outcome Measures:

Quantitive Electroencephalographic(QEEG)activity and measures of regional cerebral blood flow [ Time Frame: pre TMS and post TMS as well as post phase II, second set of TMS ] [ Designated as safety issue: No ]

Enrollment:	21
Study Start Date:	December 2000
Study Completion Date:	July 2011
Primary Completion Date:	July 2011 (Final data collection date for primary outcome measure)

Intervention Details:

treatment for 10 days

Detailed Description:

Patients will be assigned for 4 treatment arms, receiving either left high frequency plus right low frequency, or left high frequency plus right sham, or left sham, plus right low frequency, or left sham plus right sham treatment. All subjects will receive treatments for 10 days and will be followed for another 4 weeks.

Eligibility

Ages Eligible for Study:	18 Years to 65 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Major Depression
No physical health problems

Exclusion Criteria:

History of Epilepsy
Metal in the head/neck or skull
Pacemaker
Pregnancy

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00186784

Locations

Canada, Ontario
St.Joseph's Healthcare, rTMS Laboratory, Mood Disorders Program, 100 West Fifth Street
Hamilton, Ontario, Canada, L8N 3K7

Sponsors and Collaborators

St. Joseph's Healthcare Hamilton

Queen's University, Kingston, Ontario

Investigators

Principal Investigator:

Gary Hasey, MD

McMaster University

More Information

No publications provided

Responsible Party:	Dr. Gary M. Hasey, St. Joseph's Healthcare
ClinicalTrials.gov Identifier:	NCT00186784 History of Changes
Other Study ID Numbers:	TMS1871
Study First Received:	September 13, 2005
Last Updated:	August 2, 2011
Health Authority:	Canada: Health Canada

Keywords provided by St. Joseph's Healthcare Hamilton:

Repetitive Transcranial Magnetic Stimulation
TMS

Additional relevant MeSH terms:

Depression
Depressive Disorder
Behavioral Symptoms
Mood Disorders
Mental Disorders

ClinicalTrials.gov processed this record on February 12, 2012