Maximal Leg Press Strength Training Study for Coronary Artery Disease Patients

This study has been completed.

First Received on September 15, 2005. Last Updated on November 16, 2011 History of Changes

Sponsor:	Norwegian University of Science and Technology
Collaborator:	St. Olavs Hospital
Information provided by (Responsible Party):	Norwegian University of Science and Technology
ClinicalTrials.gov Identifier:	NCT00184457

Purpose

Maximal strength training has been shown to increase muscular strength, muscular volume and work economy. An 8 week maximal leg press training regime will be conducted on cardiac heart failure patients to evaluate whether they increase their maximal leg press strength, work economy, serum testosterone and quality of life. The study hypotheses are that:

Aerobic work capacity will increase due to increased work economy, without increases in maximal oxygen uptake.
Strength training will increase serum testosterone.

Condition	Intervention
Heart Failure Coronary Artery Disease	Behavioral: Strength training intervention

Study Type:	Interventional
Study Design:	Allocation: Non-Randomized Endpoint Classification: Efficacy Study Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Treatment
Official Title:	Maximal Leg Press Strength Training for Coronary Artery Disease Patients. Training Effect on Serum Testosterone and Work Economy

Resource links provided by NLM:

MedlinePlus related topics: Coronary Artery Disease Heart Failure

Drug Information available for: Testosterone Propionate Methyltestosterone Testosterone Oxymesterone Testosterone enanthate Testosterone undecanoate

U.S. FDA Resources

Further study details as provided by Norwegian University of Science and Technology:

Primary Outcome Measures:

Maximal leg press strength [ Designated as safety issue: No ]
Work economy [ Designated as safety issue: No ]
Serum testosterone [ Designated as safety issue: No ]
Quality of life [ Designated as safety issue: No ]

Enrollment:	12
Study Start Date:	September 2005
Study Completion Date:	September 2007
Primary Completion Date:	April 2007 (Final data collection date for primary outcome measure)

Eligibility

Ages Eligible for Study:	18 Years to 70 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Clinically diagnosed coronary artery disease
Stable coronary artery disease
1.5 mm depression in ST segment during a cycling strain test
Between 18-70 years of age

Exclusion Criteria:

Unstable coronary artery disease
Other limitations to exercise than coronary artery disease
Participants in other study interventions

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00184457

Locations

Norway
Norwegian University of Science and Technology
Trondheim, Norway, 7489

Sponsors and Collaborators

Norwegian University of Science and Technology

St. Olavs Hospital

Investigators

Study Director:

Asbjørn Støylen, MD

Norwegian University of Science and Technology

More Information

No publications provided

Responsible Party:	Norwegian University of Science and Technology
ClinicalTrials.gov Identifier:	NCT00184457 History of Changes
Other Study ID Numbers:	25060100
Study First Received:	September 15, 2005
Last Updated:	November 16, 2011
Health Authority:	Norway: Norwegian Social Science Data Services

Keywords provided by Norwegian University of Science and Technology:

Cardiac heart failure
Leg press
Maximal strength training
Serum testosterone
Work economy

Additional relevant MeSH terms:

Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Heart Failure
Heart Diseases
Cardiovascular Diseases
Arteriosclerosis
Arterial Occlusive Diseases

Vascular Diseases
Testosterone
Androgens
Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs
Pharmacologic Actions

ClinicalTrials.gov processed this record on February 09, 2012