A Study For Using Radiosurgery On Limited Metastases
The standard therapy in cases such as yours is surgery, radiation therapy, chemotherapy or hormonal therapy alone or in combination. The main purpose of this study is to evaluate whether radiosurgery alone affects your quality and length of life. A second purpose of this study is to determine if the levels of special types of protein (called cytokines) found in the blood are related to your quality of life during your course of treatment and follow-up.
|Study Design:||Allocation: Non-Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||A Pilot Study For Using Radiosurgery On Limited Metastases|
- To determine the feasibility and potential utility of radiosurgery for limited metastatic disease, compared to historical controls.
- Quality of life and correlation with pro-apoptotic, inflammatory, and anabolic cytokine profiles
- Analyze impact of disease bulk and number of sites involved.
|Study Start Date:||April 2001|
|Estimated Study Completion Date:||April 2006|
In this research study high dose stereotactic body radiation therapy will be directed at the site of metastasis. This treatment will be given once a day, 5 times a week (Monday through Friday) for one to four weeks depending on the location and size of the disease to be treated. Blood for the cytokine tests will be drawn before your therapy starts, weekly during therapy and at the follow-up visits as stated in the next paragraphs. Two to four tablespoons of blood will be removed each time.
|United States, New York|
|University of Rochester Department of Radiation Oncology|
|Rochester, New York, United States, 14642|
|Principal Investigator:||Paul Okunieff, MD||University of Rochester|