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Effects of Comorbid Personality Disorder on the Treatment of Bipolar I Disorder

This study has been completed.
Sponsor:
Collaborator:
University of Pittsburgh
Information provided by:
National Institute of Mental Health (NIMH)
ClinicalTrials.gov Identifier:
NCT00178061
First received: September 13, 2005
Last updated: February 22, 2006
Last verified: September 2005
History of Changes
  Purpose

This study will examine the impact of comorbid personality disorder on the outcome of treatment among patients with bipolar I disorder.


Condition Intervention Phase
Bipolar I Disorder
Borderline Personality Disorder
 Behavioral: Interpersonal Social Rhythm Therapy (IPSRT)
 Phase 4

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Treatment of Primary Mood Disorders in the Comorbidly Ill

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by National Institute of Mental Health (NIMH):

Primary Outcome Measures:
  • Hamilton Rating Scale for Depression (HRSD-25)

Secondary Outcome Measures:
  • Raskin Severity of Depression and Mania Scales

Estimated Enrollment: 13
Study Start Date: August 1997
Estimated Study Completion Date: August 2002
Detailed Description:

The major aim of this proposal is to examine the impact of comorbid personality disorder on the outcome of treatment among patients with bipolar I disorder.

The specific aims are to create a research and supervisory team and to identify potential moderators of treatment response and mediators of outcome over the course of treatment.

Members of the team will meet weekly to begin a treatment development process for enhancing Interpersonal Social Rhythm Therapy (IPSRT) for these patients. Additional assessment measures will be utilized to examine the proposed mediators and moderators of treatment.

  Eligibility

Ages Eligible for Study:   18 Years to 60 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Bipolar I Disorder with Comorbid Borderline Personality Disorder, currently manic or depressed

Exclusion Criteria:

  • Unstable Medical illness
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00178061

Locations
United States, Pennsylvania
Western Psychiatric Institute and Clinic
Pittsburgh, Pennsylvania, United States, 15213
Sponsors and Collaborators
National Institute of Mental Health (NIMH)
University of Pittsburgh
Investigators
Principal Investigator: Ellen Frank University of Pittsburgh
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00178061     History of Changes
Other Study ID Numbers: 970843-0109, 970843-0109
Study First Received: September 13, 2005
Last Updated: February 22, 2006
Health Authority: United States: Federal Government

Additional relevant MeSH terms:
Borderline Personality Disorder
Personality Disorders
Mental Disorders

ClinicalTrials.gov processed this record on May 23, 2013