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Safety Study of S-CKD602 in Patients With Advanced Malignancies

This study has been completed.
Sponsor:
Collaborator:
ALZA
Information provided by (Responsible Party):
Laura A. Pollice, University of Pittsburgh
ClinicalTrials.gov Identifier:
NCT00177281
First received: September 12, 2005
Last updated: December 18, 2013
Last verified: December 2013
  Purpose

The purpose of this research study is to evaluate a new anti-cancer drug called S CKD602, developed by ALZA Corporation. The drug is investigational and not approved by the Food and Drug administration (FDA). The side effects (the way the drug acts in your body) and the effect it has on your disease will be studied.


Condition Intervention Phase
Cancer
Drug: S CKD602
Phase 1

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Phase I Study to Evaluate the Safety and Pharmacokinetics of S-CKD602 in Patients With Advanced Malignancies

Resource links provided by NLM:


Further study details as provided by University of Pittsburgh:

Primary Outcome Measures:
  • To determine the maximum tolerated dose of S CKD602 when given every three weeks.
  • To determine the incidence and severity of toxicity of S CKD602 when given every three weeks.

Secondary Outcome Measures:
  • To determine the pharmacokinetics of CKD 602 following administration of S CKD602.

Enrollment: 45
Study Start Date: September 2003
Study Completion Date: May 2006
Primary Completion Date: May 2006 (Final data collection date for primary outcome measure)
Detailed Description:

The main purposes of this study are:

To determine the maximum tolerated dose (highest dose that can safely be given to subjects) of S CKD602 when given every three weeks.

To determine the incidence and severity of toxicity (side-effects) of S CKD602 when given every three weeks.

To determine a subject's body handles the drug (pharmacokinetics) following administration of S CKD602.

In addition to the above, we would also like to analyze how the genes (material inside each cell that is responsible for cell functioning and appearance) found in a subject's blood affect how the study drug S-CKD602 is broken down in a subject's body. This process is referred to as "metabolic genotyping analyses". This evaluation is performed using a blood sample and is optional.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

Male or female subjects with an age > 18 years Histologically or cytologically proven malignancy, unresponsive to curative surgery, radiotherapy, conventional chemotherapy or for which no conventional therapy exists. (Measurable or evaluable disease is desirable, but not required) Note: This study is restricted to patients with advanced solid tumors, subjects with hematological malignancies are excluded (including lymphoma and leukemia) ECOG Performance Status 0- 2 Adequate bone marrow function, without the support of cytokines and/or Epoetin Alpha within 5 days prior to dosing: Absolute neutrophil count (ANC) >1,500/mm3, platelet count > 100,000/mm3, Hgb > 9.0 g/dL. Adequate liver function: total bilirubin level < 2.0 mg/dL, ALT and AST < 2.0 x institutional upper limit of normal in the absence of liver metastasis, or < 4.0 x institutional upper limit of normal in the presence of liver metastasis.

Adequate renal function: serum creatinine < 1.5 mg/dL. At least 3 weeks since prior chemotherapy or cancer surgery (6 weeks for nitrosourea or mitomycin C).

Normal cardiac function with no history of uncontrolled heart disease. Women subjects (if of child bearing potential and sexually active) and male subjects (if sexually active with a partner of child bearing potential) must use medically acceptable methods of birth control prior to study entry and for the duration of the study. Medically acceptable methods of contraception that may be used by the subject and/or his/her partner include abstinence, birth control pills or patches, diaphragm and spermicide, IUD, condom and vaginal spermicide, surgical sterilization, post menopausal, vasectomy, and progestin implant or injection.

Written informed consent.

Exclusion Criteria:

Subject is pregnant or is breast feeding. Subject's life expectancy is less than 3 months. Subject exhibits confusion, disorientation, or has a history of major Psychiatric illness, which may potentially impair subject's understanding of the informed consent.

Subject has signs and symptoms of acute infection requiring systemic therapy. Subject has used another investigational agent within 30 days of dosing with S CKD602.

Subjects with known allergic reactions to camptothecin analogs, dextran sulfate or other components of S-CKD602 Symptomatic or uncontrolled brain leptomeningeal metastasis. CT scans are not required unless there is clinical suspicion of central nervous disease.

Not recovered from reversible toxicity of prior therapy. Subjects with known brain metastases because of their poor prognosis because they often develop progressive neurologic dysfunction that would confound the evaluation of neurologic and other adverse events.

Concurrent radiation therapy or radiation within 3 weeks of starting treatment with S-CKD602.

Concurrent anti-neoplastic agents.

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00177281

Locations
United States, Pennsylvania
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States, 15232
Sponsors and Collaborators
University of Pittsburgh
ALZA
Investigators
Principal Investigator: Ramesh K Ramanathan, MD University of Pittsburgh
  More Information

No publications provided

Responsible Party: Laura A. Pollice, Clinical Research Manager, University of Pittsburgh
ClinicalTrials.gov Identifier: NCT00177281     History of Changes
Other Study ID Numbers: 03-052
Study First Received: September 12, 2005
Last Updated: December 18, 2013
Health Authority: United States: Food and Drug Administration

Additional relevant MeSH terms:
Belotecan
Antineoplastic Agents
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Therapeutic Uses
Topoisomerase I Inhibitors
Topoisomerase Inhibitors

ClinicalTrials.gov processed this record on November 27, 2014