Response of Topical Capsaicin in Alopecia Areata
It has been postulated that Alopecia Areata (AA) is, at least in part, a neurologically mediated disease. Research supporting this theory includes the finding that nerves surrounding the hair follicles are collapsed. We want to take this research a step further and show that not only are these perifollicular nerves collapsed, but that their function is also impaired.
|Study Design:||Allocation: Non-Randomized
Endpoint Classification: Pharmacokinetics Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Diagnostic
|Official Title:||Perifollicular Nerves in Alopecia Areata: Response to Topical Capsaicin|
- Topical capsaicin will quantitatively decrease the amount of Substance P in the scalp of AA patients.
- The scalps of AA patients may be less sensitive to stimuli.
|Study Start Date:||August 1997|
|Estimated Study Completion Date:||June 2000|
To assess the function of perifollicular scalp nerves in AA we will look at the response of these nerves to the topical medication capsaicin. Under normal circumstances topical capsaicin is known to target nerves in the peripheral nervous system causing short-term release of the neuropeptide Substance P (SP) as well as long-term transient depletion of SP. We expect the AA patients will respond abnormally to topical capsaicin treatment.
|United States, Minnesota|
|University of Minnesota|
|Minneapolis, Minnesota, United States, 55455|
|Principal Investigator:||Maria Hordinsky, MD||University of Minnesota - Clinical and Translational Science Institute|
|Principal Investigator:||Marna Ericson, Ph D||University of Minnesota - Clinical and Translational Science Institute|