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Swallowing Pattern of Patients With Nasopharyngeal Cancer Before and After Radiation Therapy: Longitudinal Study and Correction With Saliva Amount

This study has been completed.
Sponsor:
Information provided by:
National Taiwan University Hospital
ClinicalTrials.gov Identifier:
NCT00173836
First received: September 13, 2005
Last updated: September 4, 2009
Last verified: August 2009
  Purpose

Significant evidence has shown that radiation therapy for patients with nasopharyngeal cancer (NPC) can cause swallowing abnormality. Based on our prior cross-sectional study for 184 NPC patients from 1995 to 1999, the findings of videofluoroscopic swallowing study (VFSS) revealed continuous deterioration of swallowing function of these patients even many years after radiation. We conducted a prospective study to evaluate the longitudinal change of swallowing function based on VFSS before, one month, one year and two years after completing radiation therapy. The amount of saliva was measured at the same time of VFSS study to test the relationship of decreased amount of saliva and swallowing function. Comparison of serial VFSS studies in NPC patients (n=84) and normal volunteers (n=38) were obtained. We assume that this study may reveal a complete understanding of changing swallowing patterns in the course of radiation therapy of patients with NPC. From this study, NPC patients can understand their own swallowing function. Therefore, the information may enable for earlier intervention of swallowing training or correction to avoid morbidity of radiation therapy in this patient group.


Condition
Nasopharyngeal Carcinoma

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Swallowing Pattern of Patients With Nasopharyngeal Cancer Before and After Radiation Therapy: Longitudinal Study and Correction With Saliva Amount

Resource links provided by NLM:


Further study details as provided by National Taiwan University Hospital:

Estimated Enrollment: 122
Study Start Date: August 2003
Study Completion Date: August 2006
Primary Completion Date: August 2006 (Final data collection date for primary outcome measure)
  Eligibility

Ages Eligible for Study:   20 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

Nasopharyngeal cancer patients

Criteria

Inclusion Criteria:

Nasopharyngeal cancer patients > 20 yrs.

Exclusion Criteria:

pregnant women

  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00173836

Locations
Taiwan
X-ray fluoroscopy
Taipei, Taiwan, 100
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Principal Investigator: Yeun-Chung Chang, M.D., Ph.D. National Taiwan Univserity Hospital and College of Medicine
  More Information

Publications:
Responsible Party: Yeun-Chung Chang, National Taiwan University Hospital
ClinicalTrials.gov Identifier: NCT00173836     History of Changes
Other Study ID Numbers: Yeun-Chung Chang, NSC 92-2218-E-227-001
Study First Received: September 13, 2005
Last Updated: September 4, 2009
Health Authority: Taiwan: Department of Health

Keywords provided by National Taiwan University Hospital:
Nasopharyngeal carcinoma
Saliva
Swallowing
Videofluoroscopy
Radiation

Additional relevant MeSH terms:
Carcinoma
Nasopharyngeal Neoplasms
Head and Neck Neoplasms
Nasopharyngeal Diseases
Neoplasms
Neoplasms by Histologic Type
Neoplasms by Site
Neoplasms, Glandular and Epithelial
Otorhinolaryngologic Diseases
Otorhinolaryngologic Neoplasms
Pharyngeal Diseases
Pharyngeal Neoplasms
Stomatognathic Diseases

ClinicalTrials.gov processed this record on November 25, 2014