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Angiotensin Converting Enzyme Gene Polymorphism in Children With Idiopathic Nephrotic Syndrome

This study has been completed.
Sponsor:
Information provided by:
National Taiwan University Hospital
ClinicalTrials.gov Identifier:
NCT00172276
First received: September 12, 2005
Last updated: September 14, 2005
Last verified: June 2005
History of Changes
  Purpose

Aims This study was conducted to examine the association between the ACE insertion/deletion (I/D) genotype distribution in children with idiopathic nephrotic syndrome and the response to steroid therapy.

Patients and Methods The patients with idiopathic nephrotic syndrome were divided into 2 groups according to their clinical response to steroid: SS group including infrequent and frequent relapsers and non-SS group including steroid resistant (SR) and steroid dependent (SD) patients. Children without previous renal diseases and negative proteinuria were enrolled as control group in genetic study. The genotypes for ACE gene I/D polymorphism including DD, ID and II were analyzed by the newly developed automatic denaturing high performance liquid chromatography system (DHPLC).


Condition
Nephrotic Syndrome

Study Type: Observational
Study Design: Observational Model: Case Control
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Retrospective

Further study details as provided by National Taiwan University Hospital:

  Eligibility

Ages Eligible for Study:   1 Year to 10 Years
Genders Eligible for Study:   Both
Criteria

Inclusion Criteria:

  • Total 59 children diagnosed as nephrotic syndrome at the age of 1 to 10 year-old were recruited in this study. These children with nephrotic syndrome were under follow-up at the Pediatric Nephrology Clinic in National Taiwan University Hospital. In addition, children without previous renal diseases and negative proteinuria were enrolled as control group in genetic study.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00172276

Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Principal Investigator: Yong-Kwei Tsau, MD National Taiwan University Hospital
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00172276     History of Changes
Other Study ID Numbers: 9261701241
Study First Received: September 12, 2005
Last Updated: September 14, 2005
Health Authority: Taiwan: Department of Health

Additional relevant MeSH terms:
Nephrosis, Lipoid
Nephrotic Syndrome
Nephrosis
Kidney Diseases
Urologic Diseases

ClinicalTrials.gov processed this record on June 18, 2013