An Extension Study of the Safety and Anti-leukemic Effects of Imatinib Mesylate in Patients (Male or Female ≥18 Years) With Ph + CML in Blast Crisis

This study is ongoing, but not recruiting participants.
Sponsor:
Information provided by (Responsible Party):
Novartis ( Novartis Pharmaceuticals )
ClinicalTrials.gov Identifier:
NCT00171158
First received: September 12, 2005
Last updated: April 23, 2013
Last verified: April 2013
  Purpose

This extension II study will allow for further follow-up of the disease under treatment with imatinib mesylate and allow the patients to continue to receive imatinib mesylate.


Condition Intervention Phase
Philadelphia Positive Chronic Myeloid Leukemia in Myeloid Blast Crisis
Drug: imatinib mesylate
Phase 2

Study Type: Interventional
Study Design: Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: An Extension Study of the Safety and Anti-leukemic Effects of Imatinib Mesylate in Patients (Male or Female ≥18 Years) With Ph + CML in Blast Crisis

Resource links provided by NLM:


Further study details as provided by Novartis:

Primary Outcome Measures:
  • To enable patients to have access to study drug and continue treatment [ Time Frame: until no patients are left on study ] [ Designated as safety issue: No ]

Enrollment: 20
Study Start Date: August 2004
Estimated Study Completion Date: April 2014
Estimated Primary Completion Date: April 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: imatinib mesylate Drug: imatinib mesylate
Other Name: Gleevec/Glivec

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Successful completion of the CSTI571A0102E1 study
  • Written informed consent for the extension CSTI571A0102E2

Exclusion Criteria:

  • none

Other protocol-defined inclusion/exclusion criteria may apply.

  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00171158

Locations
United States, California
UCLA
Los Angeles, California, United States, 90059
United States, Illinois
University of Chicago
Chicago, Illinois, United States, 60637
United States, Maryland
Johns Hopkins Hospital
Baltimore, Maryland, United States, 21287-8985
United States, Massachusetts
Dana Faber Institute
Boston, Massachusetts, United States, 02115
United States, Michigan
Wayne State University/Kamanos Cancer Center
Detroit, Michigan, United States, 48201
United States, North Carolina
University of North Carolina
Chapel Hill, North Carolina, United States, 27599
United States, Texas
MD Anderson Cancer Center
Houston, Texas, United States, 77030
France
Novartis Investigative Site
Poitiers, France
Germany
Novartis Investigative Site
Frankfurt/Main, Germany
Novartis Investigative Site
Leipzig, Germany
Novartis Investigative Site
Mannheim, Germany
Novartis Investigative Site
Muenchen, Germany
Italy
Novartis Investigative Site
Bologna, Italy
Novartis Investigative Site
Monza, Italy
Novartis Investigative Site
Roma, Italy
United Kingdom
Novartis Investigative Site
London, United Kingdom, W12 0NN
Novartis Investigative Site
Newcastle upon Tyre, United Kingdom, NE1 4LP
Novartis Investigative Site
Nottingham, United Kingdom, NG5 1PB
Sponsors and Collaborators
Novartis Pharmaceuticals
Investigators
Study Director: Novartis Pharmaceuticals Novartis Pharmaceuticals
  More Information

No publications provided

Responsible Party: Novartis ( Novartis Pharmaceuticals )
ClinicalTrials.gov Identifier: NCT00171158     History of Changes
Other Study ID Numbers: CSTI571A0102E2
Study First Received: September 12, 2005
Last Updated: April 23, 2013
Health Authority: United States: Food and Drug Administration

Keywords provided by Novartis:
Chronic Myelogenous Leukemia
CML
Philadelphia Chromosome
Blast crisis
Imatinib mesylate

Additional relevant MeSH terms:
Blast Crisis
Leukemia
Leukemia, Myeloid
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Neoplasms by Histologic Type
Neoplasms
Cell Transformation, Neoplastic
Neoplastic Processes
Myeloproliferative Disorders
Bone Marrow Diseases
Hematologic Diseases
Pathologic Processes
Imatinib
Antineoplastic Agents
Therapeutic Uses
Pharmacologic Actions
Protein Kinase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action

ClinicalTrials.gov processed this record on May 19, 2013