Acute Viral Respiratory Infections in Elderly
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Purpose
This study is designed to assess the causes and impact of acute respiratory illness (common colds, flu, bronchitis, pneumonia) in adults age 65 and older. One of the ways to determine the virus causing a particular illness is to get a blood specimen when a person is sick and again later and look for the body's specific responses that identify the virus. Approximately 3000 subjects will be evaluated and their medical records assessed for details of recent illness and general health to help in understanding the subjects' current illness.
| Condition |
|---|
|
Respiratory Infections, Acute |
| Study Type: | Observational |
| Study Design: | Observational Model: Cohort Time Perspective: Prospective |
| Official Title: | Etiology and Impact of Acute Viral Respiratory Infections in Ambulatory Elderly Populations |
blood, sputum, nasal and throat swabs
| Enrollment: | 3000 |
| Study Start Date: | September 2004 |
| Study Completion Date: | July 2006 |
| Primary Completion Date: | July 2006 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
|
observation
male and female adults age 65 and older with acute respiratory illness (common colds, flu, bronchitis, pneumonia)
|
Detailed Description:
The purpose of this study is to determine the role of respiratory viruses in the etiology of medically attended acute respiratory illness in elderly populations and to assess the impact of these illnesses. Ambulatory elders presenting for health care with an acute respiratory illness will be recruited. Nose and throat swab specimens will be collected to test for one of the respiratory viruses, and acute and convalescent blood specimens will be collected to test for increases in specific antibody. Specimens will be collected within seven days of the onset of illness and then 1 month later for comparison specimens. A brief questionnaire will accompany the specimens, and more complete data on the illness and consequences will be obtained from the medical record. The pattern of illnesses by virus and their severity and duration will be determined.
Eligibility| Ages Eligible for Study: | 65 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
male and female adults age 65 and older with acute respiratory illness (common colds, flu, bronchitis, pneumonia)
Inclusion Criteria:
- 65 years of age or older
- Presentation to the geriatric clinic with an acute respiratory illness of less than 7 days' duration.
Exclusion Criteria:
- Presentation to the geriatric clinic with a history of a respiratory illness of greater than 7 days' duration.
- Physician/physician assistant judgment that the respiratory complaints do not represent an acute infection.
- Patient declines to permit specimen collection.
Contacts and Locations More Information
No publications provided
| Responsible Party: | Robert Johnson, HHS/NIAID/DMID |
| ClinicalTrials.gov Identifier: | NCT00170495 History of Changes |
| Other Study ID Numbers: | 04-049, H-14802 |
| Study First Received: | September 12, 2005 |
| Last Updated: | August 26, 2010 |
| Health Authority: | United States: Federal Government |
Keywords provided by National Institute of Allergy and Infectious Diseases (NIAID):
|
respiratory illness, influenza, bronchitis, pneumonia, cold |
Additional relevant MeSH terms:
|
Respiratory Tract Infections Infection Respiratory Tract Diseases |
ClinicalTrials.gov processed this record on May 23, 2013