Coronary Artery Disease (CAD) Risk in Schizophrenia: Effect of Omega-3 Fatty Acid Supplementation
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Purpose
The purpose of this study is to determine whether the administration of omega-3 polyunsaturated fatty acids, particularly eicosapentaenoic acid (EPA), can be useful both to reduce coronary artery disease (CAD) risk and illness severity in clinically-stable patients with schizophrenia (or schizoaffective disorder), major depression or bipolar disorder (depressed phase) being treated with lipid lowering drugs (e.g., statins).
| Condition | Intervention | Phase |
|---|---|---|
|
Schizophrenia Schizoaffective Disorder Major Depression Bipolar Disorder Coronary Artery Disease |
Drug: Eicosapentaenoic acid (omega-3 fatty acid) Drug: Placebo |
Phase 2 |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Parallel Assignment Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor) Primary Purpose: Treatment |
| Official Title: | CAD Risk in Schizophrenia: Effect of Omega-3 Fatty Acid Supplementation |
- To assess whether EPA supplementation can lead to improvement in further reducing CAD risk profile [ Time Frame: 4 months ] [ Designated as safety issue: Yes ]
- To test whether EPA supplementation can simultaneously improve the psychiatric status of patients with schizophrenia [ Time Frame: 4 months ] [ Designated as safety issue: Yes ]
| Estimated Enrollment: | 60 |
| Study Start Date: | September 2005 |
| Estimated Study Completion Date: | December 2012 |
| Estimated Primary Completion Date: | December 2012 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Experimental: 1
Eicosapentaenoic acid (omega-3 fatty acid) add-on treatment group
|
Drug: Eicosapentaenoic acid (omega-3 fatty acid)
2 g of Eicosapentaenoic acid in 4 x 500 mg capsules daily for 4 months
|
| Placebo Comparator: 2 |
Drug: Placebo
2 g of Placebo (corn oil ethyl esters) in 4 x 500 mg capsules daily for 4 months
|
Detailed Description:
We propose to study the effects of EPA (2 g of EPA in 4 x 500 mg capsules daily) compared to placebo supplementation in clinically-stable schizophrenic patients being treated with statins (n=30 each) for 4 months using a randomized, double-blind design. The National Cholesterol Education Program Adult Treatment Panel III guidelines will be used to select those patients with CAD risk to participate. Clinical assessments and comprehensive assessment of the risk for CAD, including plasma total, high-density lipoprotein (HDL)- (HDL2- and HDL3-), low-density lipoprotein (LDL)- (LDL-Real-, Lp(a)-, and IDL-), and VLDL- (VLDL1,2- and VLDL3-) cholesterol, plasma triglycerides, as well as plasma homocysteine and high sensitivity C-reactive protein, will be conducted at baseline, 1 month, 2 months and 4 months after supplementation. It is anticipated that patients who receive EPA supplementation will have significantly greater reduction in plasma triglycerides and LDL4-cholesterol, and increases in HDL2-cholesterol measures, as well as improvements in psychopathology severity than those patients receiving placebo. If indeed EPA is effective in decreasing the risk of CAD, any psychiatric benefits from EPA supplementation will be a further boon to the patients and the treatment team. A tremendous advantage to the clinical use of EPA includes low cost, no significant side effects, and ease of use.
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Patients meeting Diagnostic and Statistical Manual of Mental Disorders - Fourth Edition (DSM-IV) criteria for schizophrenia (or schizoaffective disorder), major depression, or bipolar (depressed phase) disorder who are treated with antipsychotic, antidepressant or antimanic drugs and a lipid-lowering drug (statin) for 2 months or longer will be screened to participate in the proposed project.
Based upon the CAD risk determinants (see below) and the National Cholesterol Education Program (NCEP) recommendation of goals for LDL-lowering therapy, the investigators will only enroll schizophrenic patients with baseline (before statin treatment) LDL-cholesterol exceeding:
- 70 mg/dL having CAD and CAD risk equivalents, e.g., peripheral arterial disease, abdominal aortic aneurysm, symptomatic carotid artery disease, and diabetes, as well as multiple risk factors that confer a 10-year risk for CAD > 20%
- 130 mg/dL having 2 or more risk factors; and
- 160 mg/dL having less than 2 risk factors to participate in the EPA trial.
In addition, these CAD-risk patients have not reached the NCEP goal level within the past year following statin treatment.
Risk factors for CAD. The NCEP Expert Panel (NIH Publication No. 01-3670, May 2001) on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III or ATPIII) recognizes the following CAD risk factors:
- being male, 45 years or older, or being female 55 years or older;
- family history of premature CAD;
- current cigarette smoking;
- hypertension with 140/90 mmHg or greater; and
- low HDL-cholesterol (less than 40 mg/dL).
Exclusion Criteria:
- Patients with history of bleeding disorders, current drug or alcohol abuse (within one month), neurological disorders (including head injury with loss of consciousness for greater than 10 minutes), antisocial personality disorder, borderline personality disorder, or mental retardation as indicated in medical records
- Patients who are pregnant (as determined by urine pregnancy test)
- Patients who have already achieved their NCEP goal in terms of their lipid profile (as indicated in laboratory tests) will be excluded.
Contacts and Locations| Contact: Jesse Conlon, B.S. | (412)954-5787 | jesse.conlon@va.gov |
| Contact: Carol Korbanic, B.S. | (412)954-5782 | carol.korbanic@va.gov |
| United States, Pennsylvania | |
| VA Pittsburgh Healthcare System (Highland Drive) | Recruiting |
| Pittsburgh, Pennsylvania, United States, 15206 | |
| Principal Investigator: Jeffrey K Yao, Ph.D., FACB | |
| Principal Investigator: | Jeffrey K Yao, Ph.D., FACB | University of Pittsburgh and VA Pittsburgh Healthcare System |
More Information
No publications provided
| Responsible Party: | Jeffrey Yao, Research Professor of Psychiatry and Pharmaceutical Sciences, University of Pittsburgh |
| ClinicalTrials.gov Identifier: | NCT00167310 History of Changes |
| Other Study ID Numbers: | AHA 0455676U, VA IRB Protocol ID:02063 |
| Study First Received: | September 9, 2005 |
| Last Updated: | October 6, 2011 |
| Health Authority: | United States: Food and Drug Administration |
Keywords provided by University of Pittsburgh:
|
Omega-3 fatty acids Statins Antipsychotic drug Antidepressant drug |
Antimanic drug Placebos Double-blind method Bipolar (depressed phase) |
Additional relevant MeSH terms:
|
Bipolar Disorder Coronary Artery Disease Myocardial Ischemia Coronary Disease Depression Depressive Disorder Psychotic Disorders Schizophrenia Depressive Disorder, Major Affective Disorders, Psychotic Mood Disorders Mental Disorders Heart Diseases Cardiovascular Diseases |
Arteriosclerosis Arterial Occlusive Diseases Vascular Diseases Behavioral Symptoms Schizophrenia and Disorders with Psychotic Features Antidepressive Agents Antipsychotic Agents Psychotropic Drugs Central Nervous System Agents Therapeutic Uses Pharmacologic Actions Tranquilizing Agents Central Nervous System Depressants Physiological Effects of Drugs |
ClinicalTrials.gov processed this record on May 21, 2013