Molecular Mechanism of Trophinin in Cancer Invasion and Metastasis
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Purpose
Our study established a model combine the in silico biology and empirical methods to identify clinically useful biomarker from information of microarray gene expression profiles in public domain. Through this method, we found trophinin as a novel prognostic marker for early stage lung cancer, which provide insight towards the process of cancer metastasis and the potential target for treatment.
| Condition |
|---|
|
Lung Cancer |
| Study Type: | Observational |
| Study Design: | Additional Descriptors: Convenience Sample Observational Model: Natural History Time Perspective: Cross-Sectional Time Perspective: Retrospective |
| Official Title: | Molecular Mechanism of Trophinin in Cancer Invasion and Metastasis |
| Estimated Enrollment: | 150 |
| Study Start Date: | January 2005 |
| Estimated Study Completion Date: | April 2005 |
This study was to combine the in silico biology and empirical methods to identify clinically useful biomarker of lung cancer from microarray gene expression profiles in public database.
Using the expression profile of a known metastasis suppressor, CRMP-1, as a template to search for and compare transcriptome expressions in publicly accessible microarray datasets, trophinin (TRO) was identified as the best correlated gene. The expression pattern of trophinin in a lung cancer cell lines of invasion model was investigated using quantitative RT-PCR. The role of trophinin in cancer metastasis was investigated by measuring the change of invasion activity in trophinin gene-transfected cell lines. The relationship of trophinin and the clinicopathological characteristics of lung cancer were further examined by immunohistochemical staining.
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- patients who underwent surgery for non-small-cell lung cancer at the National Taiwan University Hospital from 1991 to 2000 with available stored tissue blocks were included as potential subjects in this study.
Exclusion Criteria:
-
Contacts and Locations More Information
No publications provided
| ClinicalTrials.gov Identifier: | NCT00166972 History of Changes |
| Other Study ID Numbers: | 9361701255 |
| Study First Received: | September 12, 2005 |
| Last Updated: | September 12, 2005 |
| Health Authority: | Taiwan: Department of Health |
Keywords provided by National Taiwan University Hospital:
|
metastasis, survival, malignancy, female, trophinin |
Additional relevant MeSH terms:
|
Lung Neoplasms Neoplasm Metastasis Respiratory Tract Neoplasms Thoracic Neoplasms Neoplasms by Site |
Neoplasms Lung Diseases Respiratory Tract Diseases Neoplastic Processes Pathologic Processes |
ClinicalTrials.gov processed this record on May 16, 2013