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Treatment of Melasma With Jessner's Solution vs. Trichloroacetic Acid

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2005 by Emory University.
Recruitment status was  Active, not recruiting
Sponsor:
Information provided by:
Emory University
ClinicalTrials.gov Identifier:
NCT00166192
First received: September 13, 2005
Last updated: October 8, 2009
Last verified: September 2005
History of Changes
  Purpose

Melasma is an acquired discoloration of the skin characterized by brown patches. Chemical peels using agents such as Jessner's solution and trichloroacetic acid (TCA) are commonly used to treat melasma. A chemical peel involves applying the peeling agent to the skin for a short period. The skin will peel similar to a sunburn, and moisturizers are applied to the skin. Although both agents are well-accepted, there have been no good comparisons of the two agents. The purpose of this study is determine if there is a difference in the effectiveness of these two agents.


Condition Intervention Phase
Melasma
 Procedure: Jessner's solution chemical peel
Procedure: Trichloroacetic acid chemical peel
 Phase 4

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Treatment of Melasma With Jessner's Solution vs. Trichloroacetic Acid: A Comparison of Clinical Efficacy

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Emory University:

Primary Outcome Measures:
  • Clinical efficacy by clinician's evaluation

Secondary Outcome Measures:
  • Efficacy by subject's evaluation

Estimated Enrollment: 113
Study Start Date: January 2004
  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Adults > 18 years old
  • Clinical diagnosis of melasma
  • Mental capacity to give informed consent

Exclusion Criteria:

  • Pregnancy
  • H/o allergy to Jessner's solution, tricholoracetetic acid, tretinoin, or hydroquinone
  • Active dermatitis
  • Presence of cutaneous infection
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00166192

Locations
United States, Georgia
Emory University Dermatology Clinic
Atlanta, Georgia, United States, 30322
Sponsors and Collaborators
Emory University
Investigators
Principal Investigator: Carl Washington, MD Emory University Department of Dermatology
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00166192     History of Changes
Other Study ID Numbers: 904-2003
Study First Received: September 13, 2005
Last Updated: October 8, 2009
Health Authority: United States: Food and Drug Administration

Keywords provided by Emory University:
Melasma
Jessner's solution
Trichloroacetic acid (TCA)

Additional relevant MeSH terms:
Melanosis
Hyperpigmentation
Pigmentation Disorders
Skin Diseases
Ethanol
Anti-Infective Agents, Local
 Anti-Infective Agents
Therapeutic Uses
Pharmacologic Actions
Central Nervous System Depressants
Physiological Effects of Drugs
Central Nervous System Agents

ClinicalTrials.gov processed this record on May 16, 2013