Irradiated Donor Lymphocyte Infusion in Treating Patients With Relapsed or Refractory Hematologic Cancer or Solid Tumor

This study has been completed.
Sponsor:
Collaborator:
Information provided by (Responsible Party):
Rutgers, The State University of New Jersey ( University of Medicine and Dentistry of New Jersey )
ClinicalTrials.gov Identifier:
NCT00161187
First received: September 8, 2005
Last updated: September 13, 2013
Last verified: September 2013
  Purpose

RATIONALE: When irradiated lymphocytes from a donor are infused into the patient they may help the patient's immune system kill cancer cells.

PURPOSE: This pilot study is looking at the side effects and how well irradiated donor lymphocyte infusion works in treating patients with relapsed or refractory hematologic cancer or solid tumor.


Condition Intervention Phase
Cancer
Biological: therapeutic allogeneic lymphocytes
Phase 1

Study Type: Interventional
Study Design: Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Pilot Study of Irradiated HLA-Partially Matched Allogeneic Related Donor Lymphocytes for Patients With Selected Malignancies

Resource links provided by NLM:

MedlinePlus related topics: Cancer
Genetic and Rare Diseases Information Center resources: Acute Lymphoblastic Leukemia Acute Lymphoblastic Leukemia, Childhood Acute Myelocytic Leukemia Acute Myeloid Leukemia, Adult Acute Myeloid Leukemia, Childhood Acute Non Lymphoblastic Leukemia Anaplastic Large Cell Lymphoma Angioimmunoblastic Lymphadenopathy With Dysproteinemia Angioimmunoblastic T-cell Lymphoma B-cell Lymphomas Bone Cancer Breast Cancer, Male Burkitt Lymphoma Chondrosarcoma Chronic Lymphocytic Leukemia Chronic Myeloid Leukemia Ewing's Family of Tumors Ewing's Sarcoma Follicular Lymphoma Hepatocellular Carcinoma, Childhood Hodgkin Lymphoma Hodgkin Lymphoma, Childhood Kidney Cancer Leukemia, B-cell, Chronic Leukemia, Myeloid Leukemia, T-cell, Chronic Liver Cancer Lymphoma, Large-cell Lymphomatoid Granulomatosis Lymphosarcoma Malignant Mesenchymal Tumor Mantle Cell Lymphoma Multiple Myeloma Mycosis Fungoides Myelodysplastic Syndromes Neuroepithelioma Osteosarcoma Ovarian Epithelial Cancer Ovarian Germ Cell Tumor Pancreatic Cancer Renal Cancer Sezary Syndrome Small Non-cleaved Cell Lymphoma Soft Tissue Sarcoma Stomach Carcinoma Testicular Cancer Uterine Sarcoma Waldenstrom Macroglobulinemia
U.S. FDA Resources

Further study details as provided by Rutgers, The State University of New Jersey:

Primary Outcome Measures:
  • Toxicity [ Time Frame: 10 years ] [ Designated as safety issue: Yes ]

Secondary Outcome Measures:
  • Response [ Time Frame: 10 years ] [ Designated as safety issue: No ]
  • Presence of disease or antigen-specific lymphocytes [ Time Frame: 10 years ] [ Designated as safety issue: No ]

Enrollment: 37
Study Start Date: May 2001
Study Completion Date: October 2011
Primary Completion Date: October 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Treatment
Biological/Vaccine: therapeutic allogeneic lymphocytes The total CD3+ cell dose target is 1.8 x 108 CD3+ cells/kg +/- 1.0 x 108 CD3+ cells/kg. Up to 6 cycles.
Biological: therapeutic allogeneic lymphocytes
The total CD3+ cell dose target is 1.8 x 108 CD3+ cells/kg +/- 1.0 x 108 CD3+ cells/kg. Up to 6 cycles.

Detailed Description:

OBJECTIVES:

  • Determine the toxicity of irradiated allogeneic donor lymphocyte infusion in patients with relapsed or refractory hematological cancer or solid tumor.
  • Determine the response in patients treated with this regimen.
  • Determine the presence of disease or antigen-specific lymphocytes in patients treated with this regimen.

OUTLINE: This is a pilot, open-label, controlled study.

Patients undergo irradiated allogeneic donor lymphocyte infusion over 1 hour on day 1. Treatment repeats every 8-16 weeks for up to 6 infusions in the absence of disease progression or unacceptable toxicity.

Blood samples are collected periodically and analyzed for lymphocytotoxicity directed towards patients' cells (normal and malignant cells) and for disease or antigen-specific cells. Samples are also analyzed for survival of donor lymphocytes by chimerism studies.

PROJECTED ACCRUAL: A total of 40 patients will be accrued for this study.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

DISEASE CHARACTERISTICS:

  • Histologically confirmed diagnosis of 1 of the following:

    • Hematologic cancer, including any of the following:

      • Chronic lymphocytic leukemia or small lymphocytic lymphoma meeting any of the following criteria:

        • Relapsed within 1 year after prior fludarabine phosphate-containing regimens OR not a candidate to receive such therapy due to comorbidities or allergies
        • Received prior anti-CD52 monoclonal antibody therapy OR ineligible to receive such therapy (for patients without symptomatic lymphadenopathy)
        • Has documentation of disease-associated symptoms, rapid progression of disease, or other indications for treatment
      • B- or T-cell prolymphocytic leukemia meeting any of the following criteria:

        • Relapsed within 1 year after prior fludarabine phosphate- or alkylating agent-containing regimens OR not a candidate to receive such therapy due to comorbidities or allergies
        • Relapsed within 1 year after prior anti-CD20 monoclonal antibody therapy OR ineligible to receive such therapy (for patients with CD20-positive disease)
        • Received prior anti-CD52 monoclonal antibody therapy OR ineligible to receive such therapy (for patients without symptomatic lymphadenopathy)
      • Lymphoplasmacytic lymphoma, marginal zone lymphoma, mucosa-associated lymphoid tissue lymphoma, or follicular lymphoma meeting any of the following criteria:

        • Relapsed within 1 year after prior fludarabine phosphate- or alkylating agent-containing regimens or radioconjugated anti-CD20 monoclonal antibody OR not a candidate to receive such therapy due to comorbidities or allergies
        • Relapsed within 1 year after prior anti-CD20 monoclonal antibody therapy OR ineligible to receive such therapy (for patients with CD20-positive disease)
        • Has documentation of disease-associated symptoms, rapid progression of disease, or other indications for treatment
      • Multiple myeloma meeting any of the following criteria:

        • Relapsed after prior alkylating agents, thalidomide, corticosteroids, or bortezomib OR not a candidate to receive such therapy due to comorbidities or allergies
        • Relapsed after prior high-dose chemotherapy followed by autologous hematopoietic stem cell rescue OR not a candidate to receive such therapy
      • Mantle cell lymphoma that has relapsed after prior combination chemotherapy or anti-CD20 monoclonal antibody OR not a candidate to receive such therapy
      • Diffuse large B-cell lymphoma meeting any of the following criteria:

        • Relapsed after prior salvage combination chemotherapy with or without high-dose chemotherapy followed by autologous hematopoietic stem cell rescue OR not a candidate to receive such therapy
        • Received prior radiolabeled anti-CD20 monoclonal antibody OR ineligible to receive such therapy (for patients with transformed large cell lymphoma)
      • Burkitt's lymphoma

        • Relapsed after prior salvage combination chemotherapy with or without high-dose chemotherapy followed by autologous hematopoietic stem cell rescue OR not a candidate for such therapy
      • Lymphomatoid granulomatosis or mature T-cell or NK-cell neoplasms meeting any of the following criteria:

        • Relapsed after prior single agent or combination chemotherapy OR not a candidate to receive such therapy
        • Has documentation of disease-associated symptoms, rapid progression of disease, or other indications for treatment
      • Mycosis fungoides or Sezary syndrome

        • Relapsed after prior combination chemotherapy, interferon-α, denileukin diftitox, or extracorporeal photophoresis OR not a candidate to receive such therapy
      • Anaplastic large cell lymphoma, peripheral T-cell lymphoma unspecified, or angioimmunoblastic T-cell lymphoma meeting the following criteria:

        • Relapsed after prior salvage combination chemotherapy with or without high-dose chemotherapy followed by autologous hematopoietic stem cell rescue OR not a candidate to receive such therapy
      • Hepatosplenic T-cell lymphoma or adult T-cell leukemia/lymphoma

        • Relapsed after prior salvage combination chemotherapy OR not a candidate to receive such therapy
      • Hodgkin's lymphoma

        • Relapsed after prior salvage combination chemotherapy with or without high-dose chemotherapy followed by autologous hematopoietic stem cell rescue OR not a candidate to receive such therapy
      • Acute lymphocytic leukemia meeting any of the following criteria:

        • Relapsed during or after prior multi-agent combination chemotherapy administered in sequential induction, consolidation, and maintenance courses OR not a candidate to receive such therapy
        • Relapsed after prior salvage combination chemotherapy with or without high-dose chemotherapy followed by autologous hematopoietic stem cell rescue OR not a candidate to receive such therapy
        • Relapsed after prior chemotherapy with or without radiotherapy followed by allogeneic hematopoietic stem cell transplant (or ineligible for such therapy) AND demonstrates persistent cytogenetic, fluorescent in situ hybridization (FISH), or molecular (reverse transcriptase-polymerase chain reaction) evidence of bcr-abl fusion gene despite 6 weeks of treatment with imatinib mesylate
      • Acute myelogenous leukemia or myelodysplasia meeting any of the following criteria:

        • Relapsed or refractory disease after prior induction chemotherapy (anthracycline and cytarabine, topotecan hydrochloride and cytarabine, or comparable regimen) OR not a candidate to receive such therapy
        • Not a candidate for chemotherapy with or without radiotherapy followed by allogeneic or autologous hematopoietic stem cell transplant
        • Patients with acute promyelomonocytic leukemia must have received prior tretinoin and arsenic trioxide
      • Chronic myelogenous leukemia meeting any of the following criteria:

        • Relapsed or refractory disease after prior imatinib mesylate
        • Not a candidate for chemotherapy with or without radiotherapy followed by allogeneic hematopoietic stem cell transplant
        • Chronic phase disease allowed if there is FISH or cytogenetic evidence of increasing disease
    • Solid tumor, including any of the following:

      • Renal cell carcinoma

        • Metastatic relapsed or refractory disease after prior high-dose aldesleukin OR ineligible to receive such therapy due to comorbidities OR did not consent to treatment
      • Bladder cancer or gastric cancer

        • Metastatic relapsed or refractory disease after prior combination therapy OR not a candidate to receive such therapy
      • Prostate cancer

        • Metastatic relapsed or refractory disease after prior hormonal therapy OR not a candidate to receive such therapy
      • Testicular cancer

        • Metastatic relapsed or refractory disease after prior standard induction or salvage chemotherapy or high-dose chemotherapy with autologous hematopoietic stem cell rescue OR not a candidate to receive such therapy
      • Pancreatic cancer

        • Metastatic relapsed or refractory disease after prior gemcitabine hydrochloride-based therapy OR not a candidate to receive such therapy
      • Hepatocellular carcinoma

        • Unresectable or metastatic disease
      • Colorectal carcinoma

        • Metastatic relapsed or refractory disease after prior combination therapy, including fluorouracil with or without leucovorin calcium, oxaliplatin, or irinotecan hydrochloride OR not a candidate to receive such therapy
      • Breast cancer meeting any of the following criteria:

        • Metastatic relapsed or refractory disease after prior first- or second-line standard combination chemotherapy OR not a candidate to receive such therapy
        • Received prior trastuzumab (Herceptin®) and sequential hormonal therapy OR not a candidate to receive such therapy as indicated by the biological characteristics of the cancer
      • Lung cancer (non-small cell or small cell lung cancer), ovarian cancer, endometrial cancer, or cervical cancer

        • Metastatic relapsed or refractory disease after prior first- or second-line combination chemotherapy OR not a candidate to receive such therapy
      • Malignant melanoma

        • Metastatic relapsed or refractory disease after prior immunotherapy or combination chemotherapy OR not a candidate to receive such therapy
      • Sarcoma meeting any of the following criteria:

        • Metastatic relapsed or refractory disease after prior first- or second-line combination chemotherapy OR not a candidate to receive such therapy
        • Not a candidate for resection
        • Patients with gastrointestinal stromal tumors must have received prior imatinib mesylate
  • Measurable disease
  • Must have received prior available standard therapy for specific disease OR not a candidate for this treatment
  • No CNS malignancy
  • HLA-partially matched (≥ 2/6 HLA antigen [A, B, DR]) related donor (above 18 years of age) available

PATIENT CHARACTERISTICS:

  • ECOG performance status 0-1
  • Life expectancy > 3 months
  • Bilirubin < 1.5 times upper limit of normal (ULN)
  • AST < 3.0 times ULN
  • LVEF > 35%
  • No active infections
  • Not pregnant or nursing
  • Negative pregnancy test
  • Fertile patients must use effective contraception
  • No uncontrolled medical or psychiatric illness that would preclude study compliance, in the opinion of the investigator

PRIOR CONCURRENT THERAPY:

  • See Disease Characteristics
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00161187

Locations
United States, New Jersey
Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School
New Brunswick, New Jersey, United States, 08903
Sponsors and Collaborators
University of Medicine and Dentistry of New Jersey
Investigators
Principal Investigator: Roger Strair, MD, PhD Rutgers Cancer Institute of New Jersey
  More Information

Additional Information:
No publications provided

Responsible Party: Rutgers, The State University of New Jersey ( University of Medicine and Dentistry of New Jersey )
ClinicalTrials.gov Identifier: NCT00161187     History of Changes
Other Study ID Numbers: 010101, P30CA072720, 0220003330, CDR0000540298
Study First Received: September 8, 2005
Last Updated: September 13, 2013
Health Authority: United States: Food and Drug Administration

Keywords provided by Rutgers, The State University of New Jersey:
refractory chronic lymphocytic leukemia
recurrent small lymphocytic lymphoma
prolymphocytic leukemia
extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue
nodal marginal zone B-cell lymphoma
recurrent marginal zone lymphoma
splenic marginal zone lymphoma
recurrent grade 1 follicular lymphoma
recurrent grade 2 follicular lymphoma
recurrent grade 3 follicular lymphoma
stage I multiple myeloma
stage II multiple myeloma
stage III multiple myeloma
recurrent mantle cell lymphoma
childhood diffuse large cell lymphoma
recurrent adult diffuse large cell lymphoma
recurrent adult Burkitt lymphoma
recurrent adult grade III lymphomatoid granulomatosis
recurrent childhood grade III lymphomatoid granulomatosis
adult nasal type extranodal NK/T-cell lymphoma
childhood nasal type extranodal NK/T-cell lymphoma
recurrent mycosis fungoides/Sezary syndrome
anaplastic large cell lymphoma
angioimmunoblastic T-cell lymphoma
recurrent adult T-cell leukemia/lymphoma
recurrent adult Hodgkin lymphoma
recurrent/refractory childhood Hodgkin lymphoma
recurrent adult acute myeloid leukemia
recurrent childhood acute myeloid leukemia
childhood chronic myelogenous leukemia

ClinicalTrials.gov processed this record on October 22, 2014