Skeletal Muscle Dysfunction in Heart Failure

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2005 by Ullevaal University Hospital.
Recruitment status was  Recruiting
Sponsor:
Collaborators:
Norwegian Health Assosiation
Norwegian School of Sport Sciences
The Research Council of Norway
University of Oslo
Information provided by:
Ullevaal University Hospital
ClinicalTrials.gov Identifier:
NCT00156234
First received: September 8, 2005
Last updated: NA
Last verified: September 2005
History: No changes posted
  Purpose

Patients suffering from congestive heart failure report reduced exercise capacity. This skeletal muscle dysfunction is also detectable when using small muscle groups which should not put any demand on the heart.

We hypothesize that congestive heart failure has systemic effects that causes the skeletal muscle dysfunction.


Condition Intervention
Heart Failure, Congestive
Behavioral: One-knee extension ergometer

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind
Primary Purpose: Educational/Counseling/Training
Official Title: Training and Congestive Heart Failure

Resource links provided by NLM:


Further study details as provided by Ullevaal University Hospital:

Estimated Enrollment: 45
Study Start Date: March 2005
  Eligibility

Ages Eligible for Study:   40 Years to 78 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Coronary Heart Failure
  • Ejection fraction <35%
  • NYHA 2-3
  • Spirometry FEV1 > 80%

Exclusion Criteria:

  • Cardiomyopathy
  • Transplantation candidate
  • Active malignancy
  • Restraining skeletal-muscular disease
  • Claudication in legs
  • Hospitalized last 30 days due to acute ischemic episode
  • Intravenous inotrope or vasodilatating drugs last 14 days prior to inclusion
  • AMI last 8 weeks prior to inclusion
  • Organized training last 4 months
  • Smoking on daily basis last 4 months
  • Creatinin < 150microliters/liter
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00156234

Locations
Norway
Institute for Experimental Medical Research Recruiting
Oslo, Norway, 0407
Contact: Ole M Sejersted, Professor    23 01 68 00 ext 47    o.m.sejersted@medisin.uio.no   
Contact: Per Kristian B Lunde, Post Doc    23 01 68 35 ext 47    p.k.lunde@medisin.uio.no   
Norwegian School of Sport Sciences Recruiting
Oslo, Norway, 0806
Contact: Jostein Hallén, Professor    23 26 23 14 ext 47    jostein.hallen@nih.no   
Contact: Gunnar Petersen, Ph.D student       gunnar.petersen@nih.no   
Sub-Investigator: Jostein Hallen, Professor         
Sponsors and Collaborators
Ullevaal University Hospital
Norwegian Health Assosiation
Norwegian School of Sport Sciences
The Research Council of Norway
University of Oslo
Investigators
Study Chair: Ole M Sejersted, Professor Institute for Experimental Medical Research, Ullevaal University Hospital
Study Director: Per Kristian B Lunde, Post Doc Institute for Experimental Medical Research, Ullevaal University Hospital
Study Director: Ivar Sjaastad, Post Doc Institute for Experimental Medical Research, Ullevaal University Hospital
Study Chair: Jostein Hallen, Professor Norwegian School of Sport Sciences
Principal Investigator: Morten Munkvik, Ph.D student Institute for Experimental Medical Research, Ullevaal University Hospital
Principal Investigator: Tommy A Rehn, Vit.ass. Institute for Experimental Medical Research, Ullevaal University Hospital
Principal Investigator: Gunnar S Petersen, Ph.D student Norwegian School of Sport Sciences
  More Information

No publications provided by Ullevaal University Hospital

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT00156234     History of Changes
Other Study ID Numbers: TRUST-001, Helse Øst, Helse og rehabilitering
Study First Received: September 8, 2005
Last Updated: September 8, 2005
Health Authority: Norway:National Committee for Medical and Health Research Ethics

Additional relevant MeSH terms:
Heart Failure
Cardiovascular Diseases
Heart Diseases

ClinicalTrials.gov processed this record on October 21, 2014