Developing Criteria for Cortical Resections

This study is currently recruiting participants. (see Contacts and Locations)
Verified January 2013 by University of Chicago
Sponsor:
Information provided by (Responsible Party):
University of Chicago
ClinicalTrials.gov Identifier:
NCT00152659
First received: September 7, 2005
Last updated: September 4, 2013
Last verified: January 2013
  Purpose

The purpose of this study is to study how disease processes like tumors or epilepsy spread in the brain.


Condition Intervention
Epilepsy
Tumor
Procedure: Tissue sample (procedure/screening)

Study Type: Observational
Study Design: Time Perspective: Retrospective
Official Title: Developing Functional and Structural Criteria for Cortical Resections

Resource links provided by NLM:


Further study details as provided by University of Chicago:

Primary Outcome Measures:
  • measure electrical activity in tissue sample [ Time Frame: at tissue aremoval time ] [ Designated as safety issue: No ]

Estimated Enrollment: 1000
Study Start Date: September 1998
Estimated Primary Completion Date: December 2030 (Final data collection date for primary outcome measure)
Intervention Details:
    Procedure: Tissue sample (procedure/screening)
    Tissue sampling
Detailed Description:

The purpose of this study is to study how disease processes like tumors or epilepsy spread in the brain. During surgery small pieces of abnormal (unusual) brain tissue may be removed. We analyze these specimens using more advanced microscopic and electrophysiologic techniques than are usually applied to such tissue specimens. In addition, some tissues can be maintained in laboratory conditions to allow analysis over the longer term. No extra brain tissue is taken to perform these studies. The tissue analysis is performed by the research team and are compared to the routine (normal) electrical recordings that are taken during this type of brain surgery. Currently there are no instructions telling a doctor how much brain tissue should be cut out to prevent the spread of tumors or epilepsy. We are hoping that the results of this study help us to better know how much brain tissue needs to be removed to prevent the spread of tumors or epilepsy.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Surgical candidates with epilepsy or brain tumor(s)

Criteria

Inclusion Criteria:

  • Surgical candidates with epilepsy or brain tumor(s)
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00152659

Contacts
Contact: Wim van Drongelen, Ph.D. 773-834-9049 wvandron@peds.bsd.uchicago.edu
Contact: Jan-Marino Ramirez, Ph.D. 773-702-3713 jramire@uchicago.edu

Locations
United States, Illinois
The University of Chicago Hospitals, The University of Chicago Comer Children's Hospital Recruiting
Chicago, Illinois, United States, 60637
Contact: Wim van Drongelen, Ph.D.    773-834-9049    wvandron@peds.bsd.uchicago.edu   
Contact: Jan-Marino Ramirez, Ph.D.    773-702-3713    jramire@uchicago.edu   
Principal Investigator: Wim van Drongelen, Ph.D.         
Sub-Investigator: Vernon Leo Towle, Ph.D.         
Sub-Investigator: Jan-Marino Ramirez, Ph.D.         
Sponsors and Collaborators
University of Chicago
Investigators
Principal Investigator: Wim van Drongelen, Ph.D. University of Chicago
  More Information

Publications:
Ramirez J-M, Koch H, Pena F, Drongelen W van, Tryba AK, Parkis MA, Loweth JA, Hecox KE, Kohrman MH, Frim DM, Chico MS, Marcuccilli CJ (2003) - In vitro electrophysiological differences between least and most abnormal tissue obtained from pediatric patients with intractable epilepsy. Epilepsia 44, Suppl 9: 245-246
Marcuccilli CJ, Koch H, Pena F, Drongelen W van, Tryba AK, Parkis MA, Hecox KE, Kohrman MH, Frim DM, OConnor SE, Chico MS, Ramirez J-M (2003) - Rational pharmacotherapy: relationship between in vitro electrophysiology and clinical measures. Epilepsia 44, Suppl 9: 244-245
Drongelen W van, Doren EL, Koch H, Marcuccilli CJ, Ramirez J-M, Elsen FP (2005) - Characterization of the persistent sodium current in neocortical networks of mice and humans. Abstract Washington DC: Society for Neuroscience

Responsible Party: University of Chicago
ClinicalTrials.gov Identifier: NCT00152659     History of Changes
Other Study ID Numbers: 9538
Study First Received: September 7, 2005
Last Updated: September 4, 2013
Health Authority: United States: Institutional Review Board

Keywords provided by University of Chicago:
Epilepsy
Tumor
Surgery
Brain

Additional relevant MeSH terms:
Epilepsy
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases

ClinicalTrials.gov processed this record on October 19, 2014