INTRINSIC RV - Inhibition of Unnecessary RV Pacing With AV Search Hysteresis in ICDs
INTRINSIC RV is a two-armed randomized trial that will compare the effects of innovative dual-chamber pacing with AV Search Hysteresis to standard VVI among ICD patients.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Factorial Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Inhibition of Unnecessary RV Pacing With AV Search Hysteresis in ICDs|
- Demonstrate that DDDR-AVSH is as effective as VVI with respect to the composite endpoint of death or heart failure hospitalizations.
- The following variables will be compared between patients who are randomized to either DDDR-AVSH or VVI:
- The prevalence of atrial fibrillation, Changes in medication dosage, including beta-blocker, anti-arrhythmic and coumadin medications, Programming changes, Quality of life
|Study Start Date:||July 2003|
|Estimated Study Completion Date:||October 2005|
The purpose of study is to assess whether AVSH will provide benefits of a dual-chamber ICD without the deleterious effects of unnecessary RV pacing. This study will aim to demonstrate that DDDR-AVSH is equal to VVI with respect to mortality and HF hospitalizations.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00148967
|Principal Investigator:||Brian Olshansky, MD||University of Iowa|
|Principal Investigator:||John Day, MD||Utah Heart Clinic|