Activity of the Auditory Cortex During Speech Perception and Speech Production in Stuttering

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2006 by University Hospital Muenster.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
University Hospital Muenster
ClinicalTrials.gov Identifier:
NCT00148161
First received: September 6, 2005
Last updated: April 26, 2007
Last verified: September 2006
  Purpose

The goal of the study is to examine the cortical activity during speech perception and speech production in idiopathic stutterers compared to fluent speakers. Therefore, the noninvasive method of magnetoencephalography (MEG) is used. A better understanding for the complexity of speech perception and its pathology should be developed.

Fundamental properties of stuttering are repetitions, prolongations, and blocks. In most cases stuttering emerges between 2 and 5 years of age. The auditory feedback should become less important during development, as soon as information about mispronounced words does not occur anymore. During speech development this control function should be adopted by other systems. In stutterers the dominance of the acoustic control should remain.

Brain imaging studies with positron emission tomography (PET) or magnetic resonance imaging (MRI) show defects in the network of motor system, in the lateralization of speech areas, and functions of the auditory cortex. Magnetoencephalographic studies describe a similar variety as cause of stuttering. There may be defects in the auditory feedback, a modification of the lateralization of speech areas, or an alteration of co-action of motor planning and auditory system.

The benefit of magnetoencephalography is a very good temporal resolution in the range of milliseconds combined with good spatial resolution. Therefore, it is well suited to examine the dynamics of cortical processing during stuttering. In this study evoked components of the auditory systems related to complex sounds, vocals, consonant-vocal combinations, and single words are analyzed. Differences of these components in the auditory cortices of stutterers and fluent speakers are hypothesized as well in temporal structure as in localization and lateralization.


Condition
Stuttering

Study Type: Observational
Study Design: Observational Model: Defined Population
Time Perspective: Cross-Sectional
Official Title: Evoked and Induced Auditory Cortical Activity During Speech Perception and Speech Production in Stuttering

Resource links provided by NLM:


Further study details as provided by University Hospital Muenster:

Estimated Enrollment: 20
Study Start Date: November 2004
  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Subjects with idiopathic stuttering (for the group of stutterers)
  • Fluently speaking subjects (for the control group)
  • Right handed
  • Normal hearing

Exclusion Criteria:

  • Neurological diseases
  • Psychiatric diseases
  • Medication with neurological effective drugs
  • Implants with magnetic impact
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00148161

Contacts
Contact: Antoinette G Dinnesen, Prof. Dr. +49(0)251 83 ext 56859 a.g.dinnesen@uni-muenster.de
Contact: Arne Knief, Dr. +49(0)251 83 ext 56886 knief@uni-muenster.de

Locations
Germany
Department of Phoniatrics and Pediatric Audiology, University Hospital Münster Recruiting
Münster, Germany, 48161
Contact: Antoinette G Dinnesen, Prof. Dr.    +49(0)251 83 ext 56859    a.g.dinnesen@uni-muenster.de   
Principal Investigator: Antoinette G Dinnesen, Prof. Dr.         
Principal Investigator: Arne Knief, Dr.         
Sub-Investigator: Michael Schneider         
Institute for Biomagnetism and Biosignalanalysis Recruiting
Münster, Germany, 48149
Contact: Christo Pantev, Prof. Dr.    +49(0)251 83 ext 56865    pantev@uni-muenster.de   
Principal Investigator: Christo Pantev, Prof. Dr.         
Sponsors and Collaborators
University Hospital Muenster
Investigators
Study Director: Antoinette G Dinnesen, Prof. Dr. Department of Phoniatrics and Pediatric Audiology, University Hospital Münster
Principal Investigator: Arne Knief, Dr. Department of Phoniatrics and Pediatric Audiology, University Hospital Münster
  More Information

Additional Information:
No publications provided

ClinicalTrials.gov Identifier: NCT00148161     History of Changes
Other Study ID Numbers: phonpaed001
Study First Received: September 6, 2005
Last Updated: April 26, 2007
Health Authority: Germany: Ethics Commission

Keywords provided by University Hospital Muenster:
Magnetoencephalography
Auditory cortex
Stuttering
Non stuttering

Additional relevant MeSH terms:
Stuttering
Speech Disorders
Language Disorders
Communication Disorders
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms

ClinicalTrials.gov processed this record on April 21, 2014