Psychodynamic Therapy For Co-Occurring Borderline Personality Disorder and Alcohol Use Disorder

The recruitment status of this study is unknown because the information has not been verified recently.
Verified April 2008 by State University of New York - Upstate Medical University.
Recruitment status was  Active, not recruiting
Sponsor:
Information provided by:
State University of New York - Upstate Medical University
ClinicalTrials.gov Identifier:
NCT00145678
First received: September 1, 2005
Last updated: April 11, 2008
Last verified: April 2008
  Purpose

The purpose of the study is to determine the feasibility and effectiveness of a modified form of psychodynamic psychotherapy for persons suffering from co-occurring borderline personality disorder and an alcohol use disorder.


Condition Intervention Phase
Borderline Personality Disorder
Alcohol Use Disorder
Behavioral: Psychodynamic Therapy
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Psychodynamic Therapy for Patients With Borderline Personality Disorder and Alcohol Abuse

Resource links provided by NLM:


Further study details as provided by State University of New York - Upstate Medical University:

Primary Outcome Measures:
  • episodes of parasuicide, alcohol intoxication, institutional care [ Time Frame: 12 months ] [ Designated as safety issue: Yes ]

Secondary Outcome Measures:
  • depression, dissociation, core symptoms of borderline pd, perceived social support [ Time Frame: 12 months ] [ Designated as safety issue: No ]

Enrollment: 30
Study Start Date: June 2004
Estimated Study Completion Date: May 2008
Estimated Primary Completion Date: May 2008 (Final data collection date for primary outcome measure)
Intervention Details:
    Behavioral: Psychodynamic Therapy
    Dynamic deconstructive psychotherapy is a time-limited (12-18 month) manual-based form of psychodynamic therapy that aims to remediate specific neurocognitive capacities responsible for processing of emotional experiences.
    Other Name: Dynamic Deconstructive Psychotherapy
Detailed Description:

Borderline Personality Disorder (BPD) is a condition that can cause significant distress and increased risk of death. Many persons with BPD also have an alcohol use disorder (AUD) and there is evidence that this can worsen the outcome and course of both disorders.

A manual-based form of psychodynamic therapy (PT), labeled dynamic deconstructive psychotherapy, has been developed for particularly challenging patients with BPD, especially those with co-occurring substance use disorders. It aims to remediate specific neurocognitive capacities that are responsible for processing of emotional experiences, and so diminishes symptoms of BPD and promotes the development of a coherent and differentiated self-structure. PT has been shown to be helpful for BPD, but has not been tested for people who have BPD with co-occurring substance use disorders.

The proposed study is a randomized controlled trial of PT for persons with BPD and co-occurring AUD that will generate some initial data that can be used to determine the need and feasibility for further outcome studies. Participants are randomized to either a study group receiving weekly PT or to a control group receiving usual care. Enrollment is 15 participants in each group. The study group will receive 12-18 months of PT, with naturalistic follow-up. Outcome measures are administered by a research assistant at enrollment, 3 months, 6 months, 9 months, 12 months, and 30 months.

The investigators anticipate that the PT group will show trends towards better retention in treatment and greater reduction in parasuicides, alcohol misuse, and institutional care. If so, this would have important and positive implications for the large group of patients who suffer from BPD and co-occurring AUD.

  Eligibility

Ages Eligible for Study:   18 Years to 45 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Age between 18 and 45 years
  • Meets diagnostic criteria for borderline personality disorder and for active alcohol abuse or dependence
  • At least average intelligence

Exclusion Criteria:

  • Meets diagnostic criteria for schizophrenia, or schizoaffective disorder
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00145678

Locations
United States, New York
SUNY Upstate Medical University, University Hospital
Syracuse, New York, United States, 13210
Sponsors and Collaborators
State University of New York - Upstate Medical University
Investigators
Principal Investigator: Robert J. Gregory, M.D. State University of New York - Upstate Medical University
  More Information

Publications:
Responsible Party: Robert J. Gregory, Associate Professor of Psychiatry, SUNY Upstate Medical University
ClinicalTrials.gov Identifier: NCT00145678     History of Changes
Other Study ID Numbers: SUNY UMU IRB 4968, 130230-44
Study First Received: September 1, 2005
Last Updated: April 11, 2008
Health Authority: United States: Institutional Review Board

Keywords provided by State University of New York - Upstate Medical University:
borderline
alcohol
substance
psychodynamic
psychotherapy
psychoanalytic

Additional relevant MeSH terms:
Alcohol Drinking
Personality Disorders
Borderline Personality Disorder
Drinking Behavior
Mental Disorders

ClinicalTrials.gov processed this record on August 28, 2014