Assessment of the Clinical Utility of Non Invasive Peripheral Signal Averaged Pulse Volume
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Purpose
The purpose of this study is to determine the clinical usefulness of measuring the heart's pumping ability by measuring the Peripheral Pulse Volume (PPV).
| Condition | Intervention |
|---|---|
|
Peripheral Vascular Response |
Device: Pulse Volume Measurement |
| Study Type: | Observational |
| Study Design: | Observational Model: Ecologic or Community Time Perspective: Prospective |
| Official Title: | Assessment of the Clinical Utility of Non Invasive Peripheral Signal Averaged Pulse Volume |
| Enrollment: | 16 |
| Study Start Date: | September 2004 |
| Study Completion Date: | October 2007 |
-
Device: Pulse Volume Measurement
Peripheral Pulse Volume (PPV) is the change in the volume of a limb that occurs when blood passes through the limb. The limb also acts as an electrical conductor whose electrical impedence changes with limb geometry and volume. Each time the heart beats, the volume of the limb segment changes, and therefore its electrical impedence changes. A plethysmograph can be used to measure volume changes of a part of the body by producing a plethysmographic waveform. Selectively capturing a number of these plethysmographic wave forms with acceptable noise levels and averaging them using the EKG as a reference-timing signal generate a highly reproducible pulse volume signal. Signal averaged pulse volume measurement will be obtained non-invasively from the lower extremities of patient volunteers. A disposal non-occluding electrical monitoring strap will be applied to the calf of each patient. Changes in the calf's size/volume caused by changes in the patient's cardiac output and calf blood flow will result in electrical impedance changes. These changes will be recorded by an analog admittance plethysmograph attached to the lower extremity strap. The analog plethysmograph is coupled to a digital computer for signal enhancement and measurement.
Eligibility| Ages Eligible for Study: | 18 Years to 75 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Patient who are having a right heart catherization done for other diagnostic purposes or patient in the critical care units who have Swan Ganz catheters in place for other medical management
Inclusion Criteria
- Coronary care unit patients with indwelling right heart (Swan Ganz) catheters with or without intraaortic balloon assist pumping devices.
- Congestive Heart Failure patients on and off various therapeutic inotropic agents with or without indwelling heart catheters
- Cardiac catheterization laboratory patients undergoing prophylactic IABP in the presence of left main or diffuse unstable CAD
- Chronic renal failure patients undergoing hemodialysis.
- Peripheral Vascular Disease patients
- Patients undergoing Tilt Table Testing
- Any patients undergoing right heart catheterization Exclusion criteria -- Non specified
Contacts and Locations| United States, New Jersey | |
| Robert Wood Johnson University Hospital | |
| New Brunswick, New Jersey, United States, 08901 | |
| Principal Investigator: | Sebastian Palmeri, MD | University of Medicine and Dentistry New Jersey |
More Information
Publications:
| Responsible Party: | Sebastian T. Palmeri, MD -- Principal Investigator, UMDNJ-Robert Wood Johnson Medical School |
| ClinicalTrials.gov Identifier: | NCT00143858 History of Changes |
| Other Study ID Numbers: | 4301, investigator initiated |
| Study First Received: | August 31, 2005 |
| Last Updated: | August 6, 2009 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by University of Medicine and Dentistry New Jersey:
|
Peripheral Pulse Volume |
ClinicalTrials.gov processed this record on June 18, 2013