Cetuximab in Patients With Unresectable or Metastatic Hepatocellular Carcinoma
Recruitment status was Active, not recruiting
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Purpose
The main purpose of this study is to begin to collect information and to try to learn whether or not cetuximab works in treating patients with unresectable or metastatic hepatocellular carcinoma.
| Condition | Intervention | Phase |
|---|---|---|
|
Hepatocellular Carcinoma |
Drug: Cetuximab |
Phase 2 |
| Study Type: | Interventional |
| Study Design: | Allocation: Non-Randomized Endpoint Classification: Safety/Efficacy Study Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Treatment |
| Official Title: | A Phase II Study of Cetuximab in Patients With Unresectable or Metastatic Hepatocellular Carcinoma |
- To assess the progression free survival in patients with unresectable or metastatic hepatocellular carcinoma [ Time Frame: TBD ] [ Designated as safety issue: No ]
- To evaluate the side effects of cetuximab in this population as well as the response rate, duration of response, and overall survival of patients [ Time Frame: 2 years ] [ Designated as safety issue: Yes ]
| Enrollment: | 30 |
| Study Start Date: | January 2005 |
| Primary Completion Date: | October 2005 (Final data collection date for primary outcome measure) |
-
Drug: Cetuximab
The first step in this study is to examine the tumor biopsy (previously collected) and determine whether or not it is epidermal growth factor receptor (EGFR) positive or EGFR negative. Both EGFR positive and EGFR negative patients can participate in this study because at this time it is not known whether having a negative or positive receptor makes a difference in how the study drug works on the tumor. By knowing if the tumor is EGFR positive or negative, we will be able to see if there is a difference in the way the tumor responds to cetuximab.
Patients will receive cetuximab intravenously once weekly for 6 weeks. Each 6-week period is one cycle of treatment. The first dose of cetuximab is larger than the following doses.
For the first clinic visit the patient's blood pressure, temperature, breathing and heart rate will be taken before, during, at the end, and one-hour after the cetuximab has been administered. For each visit after that, blood pressure, temperature, breathing and heart rate will be taken before and after cetuximab has been administered.
Before each administration of cetuximab, diphenhydramine will also be administered to decrease the chances of an allergic or hypersensitivity reaction.
The following tests and procedures will be performed at weeks 1, 3 and 5 during each 6-week cycle of treatments as well as at the end of study treatment: physical exam, vital signs, medical history and blood work. At the end of each 6-week cycle a CT and/or MRI will be performed to measure the tumor size.
Long-term follow-up will include physical exams and bloodwork every 6 months.
Patients will remain on cetuximab as long as there is no disease progression or intolerable side effects.
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Unresectable or metastatic hepatocellular carcinoma
- Measurable tumor
- Adequate hepatic function: total bilirubin < 3.0mg/dl; AST < 7 x upper limit of normal (ULN).
- Adequate renal function: serum creatinine < 2.0mg/dl
- Adequate bone marrow function: absolute neutrophil count (ANC) > 1,000/mm3; platelets > 75,000/mm3.
- 0-2 prior systemic chemotherapy regimens for hepatocellular carcinoma
- 18 years of age and older
- ECOG performance status of 0-2
- Life expectancy > 12 weeks
Exclusion Criteria:
- Surgery, excluding prior diagnostic biopsy or venous access device placement, within 28 days of study entry
- Uncontrolled serious medical or psychiatric illness
- Irradiation or chemotherapy for disease within 28 days of study entry
- Clinically apparent central nervous system metastases or carcinomatous meningitis
- Received an investigational agent within 30 days
- Cancer of the Liver Italian Program (CLIP) score > 3
- Acute hepatitis
- Active or uncontrolled infection
- Significant history of cardiac disease
- Prior cetuximab or other therapy which specifically and directly targets the EGFR pathway
- Prior allergic reaction to chimerized or murine monoclonal antibody therapy
Contacts and Locations| United States, Massachusetts | |
| Massachusetts General Hospital | |
| Boston, Massachusetts, United States, 02114 | |
| Dana-Farber Cancer Institute | |
| Boston, Massachusetts, United States, 02115 | |
| Beth Israel Deaconess Medical Center | |
| Boston, Massachusetts, United States, 02115 | |
| Principal Investigator: | Andrew X. Zhu, MD | Massachusetts General Hospital |
More Information
No publications provided
| Responsible Party: | Andrew Zhu, MD, Massachusetts General Hospital |
| ClinicalTrials.gov Identifier: | NCT00142428 History of Changes |
| Other Study ID Numbers: | 04-347 |
| Study First Received: | August 31, 2005 |
| Last Updated: | December 28, 2007 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by Massachusetts General Hospital:
|
Hepatocellular carcinoma cetuximab Unresectable hepatocellular carcinoma Metastatic hepatocellular carcinoma |
Additional relevant MeSH terms:
|
Carcinoma Carcinoma, Hepatocellular Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Neoplasms Adenocarcinoma Liver Neoplasms Digestive System Neoplasms |
Neoplasms by Site Digestive System Diseases Liver Diseases Cetuximab Antineoplastic Agents Therapeutic Uses Pharmacologic Actions |
ClinicalTrials.gov processed this record on May 21, 2013