Genes and Fibrinolytic Capacity of Human Endothelium

This study has been completed.
Information provided by (Responsible Party):
Nancy J. Brown, Vanderbilt University Identifier:
First received: August 29, 2005
Last updated: December 18, 2012
Last verified: December 2012

To conduct several studies on genes and the fibrinolytic capacity of human endothelium.

Condition Intervention
Cardiovascular Diseases
Heart Diseases
Blood Disease
Coronary Disease
Drug: angiotensin converting enzyme inhibitor

Study Type: Interventional
Study Design: Endpoint Classification: Pharmacokinetics/Dynamics Study
Intervention Model: Crossover Assignment
Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
Primary Purpose: Prevention
Official Title: Genes and Fibrinolytic Capacity of Human Endothelium

Resource links provided by NLM:

Further study details as provided by Vanderbilt University:

Primary Outcome Measures:
  • Net t-LA release [ Time Frame: minutes ] [ Designated as safety issue: No ]
    Net t-PA release from the forearm vasculature

Enrollment: 48
Study Start Date: August 2000
Study Completion Date: July 2008
Primary Completion Date: July 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Effect of smoking on t-PA release Drug: angiotensin converting enzyme inhibitor

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Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

No eligibility criteria

  Contacts and Locations
Please refer to this study by its identifier: NCT00139503

Sponsors and Collaborators
Vanderbilt University
Principal Investigator: Nancy Brown Vanderbilt University
  More Information


Responsible Party: Nancy J. Brown, Professor and Chair, Department of Medicine, Vanderbilt University Identifier: NCT00139503     History of Changes
Other Study ID Numbers: 245, R01HL065193
Study First Received: August 29, 2005
Last Updated: December 18, 2012
Health Authority: United States: Federal Government

Additional relevant MeSH terms:
Cardiovascular Diseases
Coronary Disease
Coronary Artery Disease
Heart Diseases
Hematologic Diseases
Myocardial Ischemia
Vascular Diseases
Arterial Occlusive Diseases
Embolism and Thrombosis
Angiotensin-Converting Enzyme Inhibitors
Enzyme Inhibitors
Protease Inhibitors
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions processed this record on April 17, 2014