Biomechanical Parameters of Gait in Patients With Parkinson's Disease and Parkinsonian Syndromes

This study has been terminated.

Sponsor:

Collaborator:

French National Institut of Health and Medical Research

Information provided by (Responsible Party):

Marie-laure Welter, Groupe Hospitalier Pitie-Salpetriere

ClinicalTrials.gov Identifier:

NCT00139321

First received: August 30, 2005

Last updated: January 7, 2013

Last verified: January 2013

History of Changes

Purpose

Gait disorders and falls are frequent in patients with parkinsonian syndromes. In patients with Parkinson's disease (PD), these signs occurred later during the course of the disease in comparison to patients with other degenerative parkinsonian disorders. The pathophysiology of these symptoms are still not fully understood. Gait initiation challenges the balance control system as the body moves from an upright stable static posture to a continuously unstable gait. The aim of this study is to analyse the gait initiation process in patients with parkinsonian disorders.

Condition	Intervention
Gait Disorders, Neurologic	Device: Force platform and electromyography

Study Type:	Interventional
Study Design:	Allocation: Non-Randomized Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Diagnostic
Official Title:	Biomechanical Parameters of Gait in Patients With Parkinson's Disease and Parkinsonian Syndromes

Resource links provided by NLM:

Genetics Home Reference related topics: Parkinson disease Perry syndrome

MedlinePlus related topics: Parkinson's Disease Walking Problems

U.S. FDA Resources

Further study details as provided by Groupe Hospitalier Pitie-Salpetriere:

Primary Outcome Measures:

Biomechanical gait initiation parameters

Estimated Enrollment:	110
Study Start Date:	June 2004
Study Completion Date:	July 2007
Primary Completion Date:	July 2007 (Final data collection date for primary outcome measure)

Eligibility

Ages Eligible for Study:	18 Years to 85 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Patients able to walk without assistance
Patients with Parkinson's disease or other degenerative parkinsonian syndromes (progressive supranuclear palsy [PSP], multiple system atrophy [MSA], corticobasal degeneration [CBD], etc.)

Exclusion Criteria:

Other parkinsonian syndromes
Dementia
Neuroleptic treatment

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00139321

Locations

France
Centre d'Investigation Clinique-Hôpital Pitié-Salpetriere
Paris, France, 75013

Sponsors and Collaborators

Groupe Hospitalier Pitie-Salpetriere

French National Institut of Health and Medical Research

Investigators

Study Director:

Yves Agid, MD, PhD

CIC-Pitié-Salpêtrière

More Information

No publications provided

Responsible Party:	Marie-laure Welter, MD, PhD, Groupe Hospitalier Pitie-Salpetriere
ClinicalTrials.gov Identifier:	NCT00139321 History of Changes
Other Study ID Numbers:	RBM0260
Study First Received:	August 30, 2005
Last Updated:	January 7, 2013
Health Authority:	France: Ministry of Health

Keywords provided by Groupe Hospitalier Pitie-Salpetriere:

Gait disorders
Postural instability
parkinsonian syndrome

Gait initiation
Parkinson's disease
Adults

Additional relevant MeSH terms:

Nervous System Diseases
Parkinson Disease
Parkinsonian Disorders
Gait Disorders, Neurologic
Basal Ganglia Diseases
Brain Diseases

Central Nervous System Diseases
Movement Disorders
Neurodegenerative Diseases
Neurologic Manifestations
Signs and Symptoms

ClinicalTrials.gov processed this record on May 19, 2013

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