Angiogenic Profile and Non-invasive Imaging May Predict Tumor Progression of High Risk Group Low Grade Glioma (LGG)

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
AHS Cancer Control Alberta
ClinicalTrials.gov Identifier:
NCT00137488
First received: August 26, 2005
Last updated: April 5, 2012
Last verified: April 2012
  Purpose

The low grade glioma (LGG) is a type of brain tumor which is generally more common in younger age group patients. Most patients with LGG undergo surgery which is mostly incomplete due to concern about loss of function. This is an incurable disease. More than half of these patients progress to a higher grade with a worse outcome within five years of their diagnosis and only one-third survive for up to ten years. Post-operative radiation treatment improves local control without survival advantage. Efforts are being made without great success to select the patients with a higher risk of progression based on physical characteristics and histological features.

Tumor vascularity is thought to be the key element in tumor progression. Tremendous progress has been made in functional imaging by using magnetic resonance imaging (MRI) 3-Tesla (3T) and in biotechnology which can be used to investigate angiogenic gene profiles in order to identify gene signature for these tumors. In this study the investigators are proposing that patients of LGG with a higher risk of tumor progression may be selected by functional imaging and angiogenic profiles. These higher risk patients may be candidates for post-operative radiation in the future with a potential survival benefit.


Condition Intervention
Glioma
Device: imaging and angiogenic profiles

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Angiogenic Profile and Non-invasive Imaging May Predict Tumor Progression of High Risk Group Low Grade Glioma (LGG)

Resource links provided by NLM:


Further study details as provided by AHS Cancer Control Alberta:

Enrollment: 10
Study Start Date: November 2005
Primary Completion Date: December 2007 (Final data collection date for primary outcome measure)
Intervention Details:
    Device: imaging and angiogenic profiles
    Image tumor angiogenesis by DCE-MRI using 1.5- or 3-T MRI instruments (13,14,15) pre-and postoperatively (before biopsy or surgery).
Detailed Description:

Summary: Comprehensive analysis of the angiogenesis-related gene expression profiles and tumor perfusion of patients with LGG will provide a novel understanding of subgroup (low and high-risk) of LGG. Thus, this study will allow identifying clinically relevant factors predictive for tumor progression and to select patients in high-risk group for adjuvant radiation therapy.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

patients referred to Cross Cancer Institute between 2004 and 2005

Criteria

Inclusion Criteria:

  • Greater than 18 years of age
  • Brain tumor with no contrast enhancement on conventional MRI and confirmed histological of LGG
  • No adjustment treatment
  • Consent to participate in study
  • No contra-indication for dynamic contrast-enhanced (DCE)-MRI
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00137488

Locations
Canada, Alberta
Cross Cancer Institute
Edmonton, Alberta, Canada, T6G 1Z2
Sponsors and Collaborators
AHS Cancer Control Alberta
Investigators
Principal Investigator: Bassam Abdulkarim, MD AHS Cancer Control Alberta
  More Information

No publications provided

Responsible Party: AHS Cancer Control Alberta
ClinicalTrials.gov Identifier: NCT00137488     History of Changes
Other Study ID Numbers: CNS-09-0024/ethics 21656
Study First Received: August 26, 2005
Last Updated: April 5, 2012
Health Authority: Canada: Health Canada

Keywords provided by AHS Cancer Control Alberta:
non-enhancing lesion
low grade glioma
high risk group selection

Additional relevant MeSH terms:
Glioma
Neoplasms
Neoplasms by Histologic Type
Neoplasms, Germ Cell and Embryonal
Neoplasms, Glandular and Epithelial
Neoplasms, Nerve Tissue
Neoplasms, Neuroepithelial
Neuroectodermal Tumors

ClinicalTrials.gov processed this record on October 30, 2014