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Comparison of Different Mucoactive Agents for the Care of the Intubated Patient in a Surgical Trauma Intensive Care Unit

This study has been completed.
Sponsor:
Information provided by:
The University of Texas Health Science Center at San Antonio
ClinicalTrials.gov Identifier:
NCT00131521
First received: August 17, 2005
Last updated: June 20, 2009
Last verified: June 2009
History of Changes
  Purpose

This study compares N-acetylcysteine (mucomyst) and sodium chloride to determine their efficacy in the prevention of pulmonary mucus obstruction and retention in intubated patients admitted to the surgical trauma intensive care unit (STICU).


Condition Intervention
Mucus Obstruction
Intubation
 Drug: mucomyst
Drug: sodium chloride (saline)

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Double-Blind
Primary Purpose: Treatment
Official Title: Comparison of Different Mucoactive Agents for the Care of the Intubated Patient in a Surgical Trauma Intensive Care Unit: A Randomized, Double Blind, Controlled Trial

Resource links provided by NLM:

MedlinePlus related topics: Injuries Wounds
U.S. FDA Resources

Further study details as provided by The University of Texas Health Science Center at San Antonio:

Primary Outcome Measures:
  • prevention of pulmonary mucus obstruction

Secondary Outcome Measures:
  • days of mechanical ventilation

Estimated Enrollment: 260
Study Start Date: January 2005
Study Completion Date: December 2007
  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Intubated and admitted to the Surgical Trauma Intensive Care Unit (STICU)
  • Subjects must be eligible to start treatment within 24 hours of their initial intubation

Exclusion Criteria:

  • Patient anticipated to be extubated within 24 hours following STICU admission
  • Hypersensitivity to acetylcysteine.
  • Pregnancy
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00131521

Locations
United States, Texas
Univesity Hospital
San Antonio, Texas, United States, 78229
Sponsors and Collaborators
The University of Texas Health Science Center at San Antonio
Investigators
Principal Investigator: John G. Myers, M.D. University of Texas Health Science Center San Antonio
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00131521     History of Changes
Other Study ID Numbers: 034-1502-320
Study First Received: August 17, 2005
Last Updated: June 20, 2009
Health Authority: United States: Institutional Review Board

Keywords provided by The University of Texas Health Science Center at San Antonio:
mucus obstruction, ventilator management

Additional relevant MeSH terms:
Acetylcysteine
Antiviral Agents
Anti-Infective Agents
Therapeutic Uses
Pharmacologic Actions
Expectorants
 Respiratory System Agents
Free Radical Scavengers
Antioxidants
Molecular Mechanisms of Pharmacological Action
Protective Agents
Physiological Effects of Drugs

ClinicalTrials.gov processed this record on June 13, 2013