The Effects of Continuous Administration of a Monophasic Oral Contraceptive on Bleeding Days and Endometrial and Ovarian Function

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Richard S. Legro, M.D., Milton S. Hershey Medical Center
ClinicalTrials.gov Identifier:
NCT00128726
First received: August 8, 2005
Last updated: December 20, 2012
Last verified: December 2012
  Purpose

The purpose of this study is to determine the safety and efficacy of a continuous combined oral contraceptive pill (CCOCP) regimen. The investigators hypothesize that there will be a decrease in the number of vaginal bleeding days in the continuous regimen compared to a traditional 21/7 regimen. In addition, the investigators hypothesize that there will be increased endometrial and ovarian suppression in the CCOCP regimen.


Condition Phase
Menstrual Cycle
Healthy
Phase 1

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Effects of Continuous Administration of a Monophasic Oral Contraceptive on Bleeding Days and Endometrial and Ovarian Function

Resource links provided by NLM:


Further study details as provided by Milton S. Hershey Medical Center:

Biospecimen Retention:   Samples With DNA

whole blood, urines, tissue


Enrollment: 62
Study Start Date: June 2001
Study Completion Date: August 2006
Detailed Description:

In the U.S. many women of reproductive age use some form of contraception, 23% of whom use estrogen-progesterone combined oral contraceptives. Low-dose oral contraceptives suppress ovulation and dominant follicle selection by inhibiting luteinizing hormone and follicle stimulating hormone secretion by the pituitary gland. Under social, cultural and religious influences, women have traditionally been prescribed oral contraceptives in a pattern of 21 days of active pills with seven days of inactive pills as a way of mimicking the natural menstrual cycle and provide reassurance of the absence of pregnancy by a withdrawal bleed during the placebo period. However, the withdrawal bleeding that occurs during the placebo period may still present with debilitating menstrual symptoms such as cramping, spotting break through bleeding, menstrual migraines and anemia. These menstrual disorders remain one of the most common reasons for prescribing the oral contraceptives. Suppression of bleeding by discarding the seven placebo tablets has been advocated for women with severe mental disabilities that impair hygiene and proper use, as well as for occasional use by women inconvenienced by menstruation (i.e. female athletes during competition and women in the military). Additionally, many physicians have used oral contraceptive pill regimens to treat endometriosis, premenstrual syndrome, anovulatory dysfunctional uterine bleeding, acne, hirsutism and anemia. The seven day pills free ovarian axis and ovarian follicular development and increase ovarian sex steroid production which may result in mild exacerbations of the treated condition. There is a growing patient preference to avoid vaginal bleeding completely, both in pre-menopausal and post-menopausal hormone replacement regimens in the general population. This is reflected in a woman's attitude about changing menstrual bleeding patterns as assessed by a 1996 Dutch survey. The majority of women in all studied age groups said that they would prefer decreasing the frequency of bleeding to less than once a month or completely eliminating menses altogether through the use of oral contraceptives. Therefore, reducing bleeding days is an important goal for improving quality of life in women suffering from the discomfort and inconvenience of withdrawal bleeding.

  Eligibility

Ages Eligible for Study:   18 Years to 35 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

Healthy women between 18-35 years of age who wish to use a continuous combined oral contraceptive and are non-smokers. Must have regular menstrual cycles for a 3 month period.

Criteria

Inclusion Criteria:

  • Healthy women of legal age of consent between 18-35 years who wish to use a continuous combined oral contraceptive and are non-smokers.
  • Must have a regular (25-31) day menstrual cycle for the three month period preceding enrollment.
  • Subject will comply with protocol, in the opinion of the investigator.

Exclusion Criteria:

  • Thrombophlebitis
  • Known or suspected clotting disorders
  • Cerebrovascular or coronary artery disease or myocardial infarction
  • Malignancy
  • Known or suspected estrogen dependent neoplasia
  • Undiagnosed abnormal genital bleeding
  • Benign or malignant liver tumor that developed during the use of oral contraceptives or other estrogen-containing products
  • Hyperlipidemia - fasting cholesterol level greater than 6.73 mmol/L (260mg); fasting triglyceride level greater than 3.39 mmol/L (300mg/dl); high cholesterol.
  • Diabetes mellitus
  • Migraine or increased sensitivity of headaches during previous estrogen or oral contraceptive study
  • Depression requiring hospitalization or associated with suicidal ideation
  • Chronic renal disease
  • Known hypersensitivity to estrogens and/or progestogens
  • Neuro-ocular disorders
  • Cholestatic jaundice
  • Pregnancy while taking oral contraceptives
  • Persistent non compliance with taking medication
  • Serious adverse experiences with oral contraceptive use
  • Malabsorption due to illness or surgery
  • Use of any experimental drug or device within the last 90 days before study drug administration
  • Any anticonvulsant medications
  • Any use of rifampin within 3 months of enrollment
  • Any use of lipid lowering agents
  • Impaired liver function or disease
  • Known or suspected pregnancy
  • Hypertension whether treated or untreated
  • Cervical cytological smear or low grade squamous intraepithelial lesion (SIL) or greater that is untreated within the last year
  • The use of an intrauterine device (IUD) or injectable or implantable estrogen, progestogens, or androgens during the six month period before enrollment; or oral contraceptive or sex hormone use within three cycles before enrollment.
  • Breast feeding
  • Known or suspected alcoholism or drug abuse
  • Smoking
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00128726

Locations
United States, Pennsylvania
The Penn State Hershey Medical Center
Hershey, Pennsylvania, United States, 17033-0850
Sponsors and Collaborators
Milton S. Hershey Medical Center
Investigators
Principal Investigator: Richard S Legro, M.D. The Penn State Hershey Medical Center/College of Medicine
  More Information

No publications provided

Responsible Party: Richard S. Legro, M.D., Professor, Obstetrics and Gynecology and Public Health Sciences, Milton S. Hershey Medical Center
ClinicalTrials.gov Identifier: NCT00128726     History of Changes
Other Study ID Numbers: HY01-190, R01 HD43332
Study First Received: August 8, 2005
Last Updated: December 20, 2012
Health Authority: United States: Institutional Review Board

Keywords provided by Milton S. Hershey Medical Center:
continuous combined oral contraceptive
endometrial and ovarian suppression

Additional relevant MeSH terms:
Contraceptive Agents
Contraceptives, Oral
Contraceptive Agents, Female
Pharmacologic Actions
Physiological Effects of Drugs
Reproductive Control Agents
Therapeutic Uses

ClinicalTrials.gov processed this record on October 23, 2014