Effects of Allergen Inhalation on Adenosine Receptor Expression in Sputum and Peripheral Blood
Recruitment status was Active, not recruiting
The purpose of this study is to determine whether asthmatics have different adenosine receptor expression profiles than healthy controls. We hypothesize that asthmatics will have increased adenosine receptor expression versus control subjects.
We also want to study the effects of allergen inhalation on adenosine receptor expression in asthmatics. We believe that adenosine receptor expression will be upregulated after allergen inhalation.
Both hypotheses are being tested in sputum and peripheral blood.
Behavioral: allergen inhalation
Behavioral: withdrawal of medication
Procedure: sputum induction
|Study Design:||Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Cross-Sectional
Time Perspective: Prospective
|Official Title:||Effects of Allergen Inhalation on Adenosine Receptor Expression and Mast Cell Activation in Peripheral Blood and Sputum of Asthmatics and Healthy Subjects|
|University Medical Center Groningen, Department of Pulmonology|
|Groningen, Netherlands, 9713 GZ|
|Principal Investigator:||Dirkje S Postma, prof. MD PhD||University Medical Center Groningen, Department of Pulmonology, hanzeplein 1, 9713 GZ Groningen, The Netherlands|