Sensory Examination and Pharmacological Modulation of Oral Hyperexcitability in Patients With Atypical Odontalgia and Matched Healthy Controls

This study has been completed.
Sponsor:
Collaborator:
Danish Pain Research Center
Information provided by:
University of Aarhus
ClinicalTrials.gov Identifier:
NCT00115102
First received: June 20, 2005
Last updated: June 15, 2006
Last verified: June 2006
  Purpose

This project examines experimental pain and chronic pain in the mouth, specifically the condition called atypical odontalgia (AO:atypical toothpain). In 16 patients with AO and 16 healthy persons, capsaicin (chili-pepper) is applied to the gingiva to cause pain. This pain is evaluated by the participants. In three sessions, 3 different medications are tested for effect on the pain. The medications are fentanyl, S-ketamine and placebo-treatment (saline). The aim is to know more about pain mechanisms in AO in order to develop an effective treatment.


Condition Intervention Phase
Odontalgia
Drug: fentanyl
Drug: S-ketamine
Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double-Blind
Primary Purpose: Diagnostic

Resource links provided by NLM:


Further study details as provided by University of Aarhus:

Primary Outcome Measures:
  • Pain
  • Sensitivity to heat and cold
  • Sensitivity to mechanical stimuli

Estimated Enrollment: 20
Study Start Date: March 2004
Estimated Study Completion Date: October 2005
  Eligibility

Ages Eligible for Study:   18 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Atypical odontalgia

Exclusion Criteria:

  • BMI > 30
  • Heart conditions
  • Lung disease
  • Diseases of the liver or kidneys
  • Hypertension, untreated
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00115102

Locations
Denmark
Danish Pain Research Center
Aarhus, Denmark, DK-8000
Sponsors and Collaborators
University of Aarhus
Danish Pain Research Center
Investigators
Study Chair: Troels Staehelin Jensen, MD, PhD, Dr.Sci Aarhus University Hospital
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00115102     History of Changes
Other Study ID Numbers: AO1
Study First Received: June 20, 2005
Last Updated: June 15, 2006
Health Authority: Denmark: Danish Medicines Agency

Keywords provided by University of Aarhus:
Atypical odontalgia
capsaicin
pain
neuropathic pain

Additional relevant MeSH terms:
Toothache
Facial Pain
Pain
Signs and Symptoms
Stomatognathic Diseases
Tooth Diseases

ClinicalTrials.gov processed this record on October 21, 2014