The Effect of Folic Acid on Atherosclerosis, Cognitive Performance and Hearing
The purpose of this study is to determine if folic acid supplementation can slow down atherosclerotic progression, age-related cognitive decline and age-related hearing loss.
Age-Related Memory Disorder
Behavioral: folic acid (0.8 mg)
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Primary Purpose: Prevention
|Official Title:||The Folic Acid and Carotid Intima-Media Thickness (FACIT) Study: A Randomized Controlled Trial|
- Change in mean carotid intima-media thickness
- Change in maximum carotid intima-media thickness
- Change in carotid distension
- Change in hearing levels (pure tone air conduction averages of 0.5, 1, and 2 kHz & 4, 6 and 8 kHz)
- Cognitive performance at year 3 (cognitive domains: simple speed, cognitive flexibility, and memory; and information processing speed and semantic memory)
- Inflammatory markers and hemostasis markers
|Study Start Date:||September 2000|
|Estimated Study Completion Date:||December 2004|
Low levels of B vitamins, in particular folate, and high levels of plasma total homocysteine, have been associated with a variety of age-related diseases and disorders, including cardiovascular disease, dementia and hearing impairment. Extra folate, for example in the form of folic acid, is known to decrease the concentrations of plasma total homocysteine.
We examined whether 0.8 mg/d folic acid could slow down atherosclerotic progression and the above mentioned age-related processes.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00110604
|Wageningen, Gelderland, Netherlands, 6700 EV|
|Principal Investigator:||Petra Verhoef, PhD||Wageningen Centre for Food Sciences|