Marijuana Treatment Project - 3 (MTP-3)

This study has been completed.
Sponsor:
Collaborator:
Information provided by (Responsible Party):
Mark Litt, University of Connecticut Health Center
ClinicalTrials.gov Identifier:
NCT00107588
First received: April 5, 2005
Last updated: January 7, 2014
Last verified: January 2014
  Purpose

The goal of this research is to improve treatment outcome for marijuana-dependent individuals. The current study builds on the findings of our prior NIDA-funded marijuana treatment study in which improved client outcomes were associated with greater treatment attendance, greater client self-efficacy, and greater use of coping skills. We will use a contingency management paradigm to provide tangible reinforcement for completing homework assignments that are designed to enhance coping skills. It is anticipated that this will result in greater homework compliance, leading to greater self-efficacy regarding one's ability to cope with high-risk situations. Improved self-efficacy will enhance the likelihood of employing coping skills in high-risk situations, thereby increasing the probability of achieving and maintaining abstinence.


Condition Intervention
Marijuana Dependence
Behavioral: Reinforcement for homework completion
Behavioral: Reinforcement for Abstinence
Behavioral: Case Management

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Contingency Management for Marijuana Dependence

Resource links provided by NLM:


Further study details as provided by University of Connecticut Health Center:

Primary Outcome Measures:
  • Marijuana abstinence [ Time Frame: One-year follow-up period ] [ Designated as safety issue: No ]
  • Self-efficacy, use of coping skills, and treatment attendance [ Time Frame: During 2-month treatment period ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Continuous abstinence will be predicted by (a) treatment attendance; (b) posttreatment self-efficacy for coping; and (c) use of coping skills [ Time Frame: One-year follow-up period ] [ Designated as safety issue: No ]

Estimated Enrollment: 234
Study Start Date: February 2007
Study Completion Date: August 2012
Primary Completion Date: April 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Reinforcement for homework completion Behavioral: Reinforcement for homework completion
Provides contingent reinforcement for engaging in homework activities designed to enhance coping skills
Active Comparator: Reinforcement for Abstinence Behavioral: Reinforcement for Abstinence
Provides contingent reinforcement for submitting marijuana-free urine specimen
Active Comparator: Case Management Behavioral: Case Management
Will control for the effect of therapist-client contact by providing supportive case management as an active control condition.

Detailed Description:

Participants will receive an intervention combining one session of motivational enhancement therapy with eight sessions of cognitive-behavioral coping skills therapy (MET+CBT). A contingency management procedure will be added to this intervention, providing reinforcement for completion of homework, as verified by call-ins to an Interactive Voice Recording (IVR) system. Outcomes will be compared to an MET+CBT intervention in which reinforcement will be provided for marijuana-free urine specimens, and to a control group that receives Case Management. Recruitment of 234 marijuana-dependent participants will occur over a three-year period. They will be randomly assigned to one of the three 9-session interventions. Treatment will be individual, manualized, and provided on an outpatient basis. Pretreatment assessments will obtain baseline data; follow-up assessments at three-month intervals for one year will evaluate marijuana use outcomes, other drug or alcohol use, and psychosocial functioning. It is anticipated that the intervention in which completion of homework is reinforced will result in the best outcomes. The mechanisms by which the interventions result in behavior change will be the specific focus of attention in this study.

  Eligibility

Ages Eligible for Study:   18 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Cannabis dependence
  • Willing to accept random assignment to interventions

Exclusion Criteria:

  • Current dependence on alcohol or other drugs
  • Problems that require inpatient hospitalization
  • Reading ability below fifth grade level
  • Lack of reliable transportation to treatment
  • Excessive commuting distance
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00107588

Locations
United States, Connecticut
University of Connecticut Health Center
Farmington, Connecticut, United States, 06030-3910
Sponsors and Collaborators
University of Connecticut Health Center
Investigators
Principal Investigator: Mark D Litt, Ph.D. University of Connecticut Health Center
  More Information

No publications provided

Responsible Party: Mark Litt, Professor, University of Connecticut Health Center
ClinicalTrials.gov Identifier: NCT00107588     History of Changes
Other Study ID Numbers: NIDA-12728-06, R01DA012728-06, R01-12728-06
Study First Received: April 5, 2005
Last Updated: January 7, 2014
Health Authority: United States: Federal Government

Keywords provided by University of Connecticut Health Center:
marijuana dependence
self-efficacy
coping skills
attendance
marijuana abstinence

Additional relevant MeSH terms:
Marijuana Abuse
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders

ClinicalTrials.gov processed this record on October 01, 2014