AZD2171 and Chemotherapy in Treating Patients With Advanced Non-Small Cell Lung Cancer, Colorectal Cancer, or Other Cancer Suitable for Treatment With Capecitabine (Non-Small Lung Cancer Patients Closed to Enrollment as 8/9/07)

This study has been completed.
Sponsor:
Information provided by:
NCIC Clinical Trials Group
ClinicalTrials.gov Identifier:
NCT00107250
First received: April 5, 2005
Last updated: January 18, 2011
Last verified: January 2011
  Purpose

RATIONALE: AZD2171 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Drugs used in chemotherapy, such as paclitaxel, carboplatin, or capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving AZD2171 together with chemotherapy may kill more tumor cells.

PURPOSE: This phase I trial is studying the side effects and best dose of AZD2171 when given together with chemotherapy in treating patients with advanced non-small cell lung cancer (closed to enrollment as of 8/9/07), colorectal cancer, or other cancer suitable to capecitabine treatment.


Condition Intervention Phase
Colorectal Cancer
Lung Cancer
Unspecified Adult Solid Tumor, Protocol Specific
Drug: capecitabine
Drug: carboplatin
Drug: cediranib maleate
Drug: paclitaxel
Phase 1

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Phase I, Open-Label, Dose-Seeking Study of AZD2171 Given Daily Orally in Combination With Standard Chemotherapy Regimens (CT) in Patients With Advanced Incurable Non-Small Cell Lung Cancer (NSCLC) or Colorectal Cancer or Other Tumor Types Suitable for Treatment With Capecitabine

Resource links provided by NLM:


Further study details as provided by NCIC Clinical Trials Group:

Primary Outcome Measures:
  • Dose limiting toxicity [ Time Frame: Each dose level ] [ Designated as safety issue: Yes ]
    To recommend phase II dose of AZD2171 when given orally daily in combination with standard chemotherapy in patients with advanced NSCLC or colon cancer or other tumour types suitable for treatment with capecitabine.


Secondary Outcome Measures:
  • Safety [ Time Frame: Each dose level ] [ Designated as safety issue: Yes ]
    safety, tolerability, toxicity profile, dose limiting toxicities and pharmacokinetic profile of AZD2171 and standard chemotherapy given in these combinations. The correlation, if any,between the toxicity profile and the pharmacokinetics will be determined.

  • Anti-tumour activity [ Time Frame: Each dose level ] [ Designated as safety issue: No ]
    Assessing the anti-tumour activity of AZD2171 in combination with standard chemotherapy regimens in patients with measurable disease.

  • Tumour Response [ Time Frame: Each dose level ] [ Designated as safety issue: No ]
    To correlate patient outcomes (response) with baseline (tumour) and serial (urine and plasma) biomarkers


Enrollment: 50
Study Start Date: January 2005
Study Completion Date: January 2011
Primary Completion Date: January 2011 (Final data collection date for primary outcome measure)
Intervention Details:
    Drug: capecitabine
    1000 mg/m2 orally twice daily (total of 2000 mg/m2 per day) for the first 14 days of a 21 day cycle for a maximum of 6-8 cycles.
    Drug: carboplatin
    AUC 6; IV; 30 minutes; Every 21 days for a maximum of 6-8 cycles
    Drug: cediranib maleate
    Given daily; orally with approximately 240 ml of water whilst in an upright position
    Drug: paclitaxel
    200mg/m2; IV; 3 hours; Every 21 days for a maximum of 6-8 cycles
Detailed Description:

OBJECTIVES:

  • Determine the maximum tolerated dose and recommended phase II dose of AZD2171 when administered in combination with standard chemotherapy comprising either paclitaxel and carboplatin OR capecitabine in patients with advanced incurable non-small cell lung cancer (closed to accrual as of 8/9/07), colorectal cancer, or other tumor types suitable for treatment with capecitabine.
  • Determine the safety and tolerability of these regimens in these patients.
  • Determine the toxicity profile and dose-limiting toxic effects of these regimens in these patients.
  • Determine the pharmacokinetic profile of these regimens in these patients.
  • Correlate the toxicity profile with the pharmacokinetic profile of these regimens in these patients.
  • Determine the antitumor activity of these regimens in patients with measurable disease.
  • Correlate patient outcome (response) with baseline (using tumor samples) and serial (using urine and plasma samples) biomarkers in patients treated with these regimens.

OUTLINE: This is an open-label, multicenter, dose-escalation study of AZD2171. Patients are assigned to 1 of 2 treatment groups according to diagnosis.

  • Group 1 (non-small cell lung cancer) (closed to accrual as of 8/9/07): Patients receive paclitaxel IV and carboplatin IV on day 1. Patients also receive oral AZD2171 once daily on days 2-21 of course 1 and on days 1-21 of all subsequent courses. Treatment with paclitaxel and carboplatin repeats every 21 days for up to 8 courses in the absence of disease progression or unacceptable toxicity. Treatment with AZD2171 repeats every 21 days in the absence of disease progression or unacceptable toxicity.
  • Group 2 (colorectal or other tumor types): Patients receive oral capecitabine twice daily on days 1-14. Patients also receive oral AZD2171 once daily on days 8-21 of course 1 and on days 1-21 of all subsequent courses. Treatment with capecitabine repeats every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. Treatment with AZD2171 repeats every 21 days in the absence of disease progression or unacceptable toxicity.

In both groups, patients achieving a complete response (CR) OR a stable partial response (SPR) receive 2 additional courses beyond CR or SPR.

Cohorts of 3-6 patients per group receive escalating doses of AZD2171 until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 6 patients experience dose-limiting toxicity. Up to 30 additional patients (20 in group 1 and 10 in group 2) will be treated at the MTD.

After completion of study treatment, patients are followed at 4 weeks and then every 3 months until disease relapse.

PROJECTED ACCRUAL: A total of 3-35 patients will be accrued for this study.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

DISEASE CHARACTERISTICS:

  • Histologically or cytologically confirmed diagnosis of 1 of the following:

    • Non-small cell lung cancer (NSCLC) (closed to accrual as of 8/9/07) meeting 1 of the following stage criteria:

      • Stage IIIB disease

        • Patients without pleural effusion who are not candidates for combined modality treatment OR who were treated at centers where combined modality treatment is not considered standard treatment are eligible
      • Stage IV disease
      • Local or metastatic failure after prior surgery and/or radiotherapy
    • Colorectal cancer

      • Metastatic disease
      • Considered suitable for first-line therapy with capecitabine
    • Other tumor types

      • Suitable for treatment with capecitabine
      • No more than 2 prior chemotherapy regimens for advanced or metastatic disease
  • Incurable by radiotherapy or surgery
  • Clinically or radiologically documented disease

    • No tumor marker elevation as the only evidence of disease
  • No necrotic or hemorrhagic tumor or metastases
  • No untreated brain or meningeal metastases

    • Patients with previously treated stable brain metastases (by radiography or clinical exam) are eligible provided they are asymptomatic and do not require corticosteroids

PATIENT CHARACTERISTICS:

Age

  • 18 and over

Performance status

  • ECOG 0-2

Life expectancy

  • At least 12 weeks (colorectal cancer patients)

Hematopoietic

  • Hemoglobin adequate

    • Anemia allowed provided patient is well compensated with no evidence of recent bleeding
  • Absolute granulocyte count ≥ 1,500/mm^3
  • Platelet count ≥ 100,000/mm^3
  • No overt bleeding (i.e., ≥ 30 mL/episode) within the past 3 months

Hepatic

  • Bilirubin ≤ 1.5 times upper limit of normal (ULN)
  • ALT or AST ≤ 2 times ULN (5 times ULN for documented liver metastases)

Renal

  • Creatinine ≤ 1.5 times ULN OR
  • Creatinine clearance ≥ 50 mL/min
  • No proteinuria > grade 1

Cardiovascular

  • Resting systolic blood pressure ≤ 150 mm Hg AND/OR resting diastolic blood pressure ≤ 100 mm Hg (in the presence or absence of a stable dose of antihypertensive medication)
  • Mean QTc ≤ 470 msec (with Bazetts correction) by ECG
  • LVEF > 50% for patients with prior anthracyclines/trastuzumab or cardio-toxic agents
  • No untreated or uncontrolled cardiovascular condition
  • No symptomatic cardiac dysfunction
  • No poorly controlled hypertension
  • No history of labile hypertension
  • No history of poor compliance with antihypertensive medication
  • No history of familial long QT syndrome

Pulmonary

  • No clinically relevant hemoptysis (i.e., ≥ 5 mL fresh blood) within the past 4 weeks

    • Patients with only flecks of blood in their sputum are eligible

Other

  • Not pregnant or nursing
  • Negative pregnancy test
  • Fertile patients must use effective (double-method for females; barrier method for males) contraception
  • No prior allergic reaction to drugs containing Cremophor EL® (NSCLC patients [closed to accrual as of 8/9/07])
  • No peripheral neuropathy > grade 1 (NSCLC patients [closed to accrual as of 8/9/07])
  • No dihydropyrimidine dehydrogenase deficiency (colorectal cancer patients)
  • No history of severe hand-foot syndrome after treatment with fluoropyrimidines (colorectal cancer patients)
  • No other malignancy within the past 5 years except adequately treated nonmelanoma skin cancer or other curatively treated solid tumor
  • No active or uncontrolled infection
  • No other serious illness or medical condition that would preclude study participation

PRIOR CONCURRENT THERAPY:

Biologic therapy

  • No prior antiangiogenesis therapy

Chemotherapy

  • At least 4 weeks since prior single-agent non-platinum-containing chemotherapy (6 weeks for nitrosoureas or mitomycin) for metastatic disease (NSCLC patients [closed to accrual as of 8/9/07])

    • No more than 1 prior single-agent non-platinum-containing chemotherapy regimen for metastatic disease
  • At least 6 months since prior adjuvant or neoadjuvant chemotherapy
  • No prior taxane therapy (NSCLC patients [closed to accrual as of 8/9/07])
  • No prior chemotherapy for metastatic disease (colorectal cancer patients)
  • No prior capecitabine (colorectal cancer patients)

Endocrine therapy

  • See Disease Characteristics
  • At least 4 weeks since prior corticosteroids

Radiotherapy

  • See Disease Characteristics
  • At least 21 days since prior palliative radiotherapy except for low-dose non-myelosuppressive radiotherapy with approval
  • At least 6 months since prior adjuvant radiotherapy

Surgery

  • See Disease Characteristics
  • At least 14 days since prior major surgery

Other

  • Recovered from prior therapy
  • At least 14 days since prior epidermal growth factor receptor inhibitor therapy
  • Concurrent oral anticoagulants (e.g., warfarin) allowed provided INR is strictly monitored
  • No other concurrent investigational therapy
  • No other concurrent anticancer therapy
  • No concurrent prophylactic pyridoxine (vitamin B_6) for hand-foot syndrome (colorectal or other tumor type patients)

    • Use of pyridoxine after the onset of hand-foot syndrome allowed at the discretion of the physician
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00107250

Locations
Canada, Ontario
Ottawa Hospital Regional Cancer Centre - General Campus
Ottawa, Ontario, Canada, K1H 8L6
Princess Margaret Hospital
Toronto, Ontario, Canada, M5G 2M9
Sponsors and Collaborators
NCIC Clinical Trials Group
Investigators
Study Chair: Derek Jonker, MD Ottawa Regional Cancer Centre
Study Chair: Scott A. Laurie, MD, FRCPC Ottawa Regional Cancer Centre
  More Information

Additional Information:
No publications provided

Responsible Party: Ralph Meyer, M.D., NCIC Clinical Trials Group
ClinicalTrials.gov Identifier: NCT00107250     History of Changes
Other Study ID Numbers: I171, CAN-NCIC-IND171, CDR0000422357
Study First Received: April 5, 2005
Last Updated: January 18, 2011
Health Authority: Canada: Health Canada

Keywords provided by NCIC Clinical Trials Group:
recurrent non-small cell lung cancer
stage IIIB non-small cell lung cancer
stage IV non-small cell lung cancer
stage IV colon cancer
stage IV rectal cancer
unspecified adult solid tumor, protocol specific

Additional relevant MeSH terms:
Carcinoma, Non-Small-Cell Lung
Colorectal Neoplasms
Lung Neoplasms
Carcinoma, Bronchogenic
Bronchial Neoplasms
Respiratory Tract Neoplasms
Thoracic Neoplasms
Neoplasms by Site
Neoplasms
Lung Diseases
Respiratory Tract Diseases
Intestinal Neoplasms
Gastrointestinal Neoplasms
Digestive System Neoplasms
Digestive System Diseases
Gastrointestinal Diseases
Colonic Diseases
Intestinal Diseases
Rectal Diseases
Maleic acid
Cediranib
Capecitabine
Carboplatin
Paclitaxel
Fluorouracil
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Antineoplastic Agents
Therapeutic Uses

ClinicalTrials.gov processed this record on August 26, 2014