Exercise Training and Walking Ability After Chronic Stroke

This study has been completed.
Sponsor:
Information provided by:
University of Sydney
ClinicalTrials.gov Identifier:
NCT00107068
First received: April 4, 2005
Last updated: June 23, 2005
Last verified: April 2005
  Purpose

This study will investigate the efficacy of aerobic exercise and progressive resistance training (PRT), singularly and combined, on changes in walking endurance for mildly-to-moderately affected chronic stroke patients. Specifically, we will determine the relative importance of training induced changes in muscle strength versus aerobic fitness on increases in gait velocity and 6-min walking distance, and assess the concomitant functional and psychosocial impact of increased muscle strength, aerobic fitness and improved gait. This longitudinal study will be conducted as a double blinded factorial randomized controlled trial of exercise training for chronic stroke patients.


Condition Intervention
Stroke
Procedure: [A] Aerobic isokinetic cycling exercise
Procedure: [B] Progressive Resistance Training
Procedure: [A] + [B]

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Bio-equivalence Study
Intervention Model: Factorial Assignment
Masking: Double-Blind
Primary Purpose: Treatment
Official Title: Does Aerobic or Resistance Exercise Training Improve Walking Ability in Chronic Stroke Patients?

Resource links provided by NLM:


Further study details as provided by University of Sydney:

Primary Outcome Measures:
  • Subjects will undertake a 6 min walking test for maximum distance

Secondary Outcome Measures:
  • Cardiorespiratory Fitness
  • Lower limb muscular strength and endurance
  • Mobility variables
  • Scales and questionnaires

Estimated Enrollment: 48
Study Start Date: January 2001
Estimated Study Completion Date: May 2004
  Show Detailed Description

  Eligibility

Ages Eligible for Study:   45 Years to 90 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Age > 45 years
  • First stroke resulting in hemiplegia
  • At least 4-months post stroke
  • Residing at home or community-based (non-institutionalized) living environment
  • Self selected gait velocity between 0.42 m/s to 0.80 m/s
  • No longer receiving physiotherapy.
  • Adequate comprehension of instructions and perceptual abilities (assessed by stroke clinician during medical screening), no significant musculotendinous or bony restrictions of the affected limb, nor any serious chronic disease independently causing significant disability or profound atrophy of the affected limb will comprise further indications to participation

Exclusion Criteria:

  • Subjects will be excluded if they have significant cardiac disease, symptom limiting peripheral vascular disease, or any of the exclusion criteria contraindicating moderate exercise as outlined by the American College of Sports Medicine guidelines for cardiac disease rehabilitation or for frail and elderly adults. The initial symptom-limited/maximal aerobic assessment will serve as the screening test for contraindications to further exercise.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00107068

Locations
Australia, New South Wales
Rehabilitation Research Centre, University of Sydney
Sydney, New South Wales, Australia, 2141
Sponsors and Collaborators
University of Sydney
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00107068     History of Changes
Other Study ID Numbers: NHMRC 153970, NHMRC 153970
Study First Received: April 4, 2005
Last Updated: June 23, 2005
Health Authority: Australia: Department of Health and Ageing Therapeutic Goods Administration

Keywords provided by University of Sydney:
Stroke
Exercise
Aerobic
PRT
Walking ability

Additional relevant MeSH terms:
Stroke
Cerebral Infarction
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases
Brain Infarction
Brain Ischemia

ClinicalTrials.gov processed this record on April 22, 2014