Consortium On Risk for Early-onset Parkinson's Disease (CORE PD)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified January 2012 by Columbia University.
Recruitment status was  Recruiting
Sponsor:
Collaborator:
Information provided by (Responsible Party):
Columbia University
ClinicalTrials.gov Identifier:
NCT00104585
First received: March 1, 2005
Last updated: January 18, 2012
Last verified: January 2012
  Purpose

The purpose of this study is to investigate genetic and environmental risk factors that increase susceptibility to the development of early-onset Parkinson's disease (developed at or before age 50).


Condition
Parkinson's Disease

Study Type: Observational
Study Design: Observational Model: Family-Based
Time Perspective: Cross-Sectional
Official Title: Genetic Epidemiology of Parkinson's Disease

Resource links provided by NLM:


Further study details as provided by Columbia University:

Biospecimen Retention:   Samples With DNA

whole blood


Estimated Enrollment: 800
Study Start Date: July 2004
Estimated Primary Completion Date: September 2012 (Final data collection date for primary outcome measure)
Groups/Cohorts
1
People with young onset Parkinson's disease and their family members

Detailed Description:

Parkinson's disease (PD) is a common, neurodegenerative condition. Although mostly a late-onset disorder, 10 percent of people with PD are reported to develop symptoms before the age of 50. To date, six genes have been found to be associated with PD, however the majority have been found in rare PD 'families'. Some studies have also identified a number of environmental risk factors, such as pesticide use, that appear to increase the risk of PD.

In a previous study, Dr. Karen Marder and her research team found that close family members of people with both early- and late-onset PD have a three-fold increased risk of PD compared to close family members of people without PD.

The purpose of the Consortium On Risk for Early-onset Parkinson's Disease (CORE PD) study is to identify the genetic factors that contribute to the development of early-onset Parkinson's disease, and to understand how these genetic factors interact with other genes and the environment to cause PD.

Participation in the study involves a blood draw (to look for genetic factors associated with PD), questionnaires collecting information on family and medical history, and a neurological examination. In addition participants may be contacted in the future and asked to participate in a more detailed interview. At that time, study investigators will also ask participants for permission to contact family members to invite them to participate in the study.

This research study requires participants to sign a consent form, which states that the research is voluntary and confidential. In addition, since this is a research study, genetic results are not released to participants or their family members now or in the future.

Scientists hope this multi-center study will increase the current knowledge of PD and that the identification of factors that cause PD will lead to better diagnosis and treatment.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Young onset PD patients

Criteria

Inclusion Criteria:

  • Any person with Parkinson's disease in the United States whose symptoms began at age 50 or younger and was diagnosed by a neurologist.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00104585

Contacts
Contact: Helen Mejia-Santana, M.A. 877-305-2438 research@corepdstudy.org

Locations
United States, California
The Parkinson's Institute Active, not recruiting
Sunnyvale, California, United States, 94089
United States, Connecticut
The Institute for Neurodegenerative Disorders Active, not recruiting
New Haven, Connecticut, United States, 06510
United States, Illinois
Rush University Medical Center Recruiting
Chicago, Illinois, United States, 60612
Contact: Lucia M. Blasucci    312-563-2900    Lucia_M_Blasucci@rush.edu   
Glenbrook Hospital, Evanston Active, not recruiting
Glenview, Illinois, United States, 60026
United States, Maryland
Johns Hopkins Hospital Active, not recruiting
Baltimore, Maryland, United States, 21287
United States, Minnesota
Struthers Parkinson's Center Active, not recruiting
Golden Valley, Minnesota, United States, 55427
United States, New York
Beth Israel Medical Center Active, not recruiting
New York, New York, United States, 10003
Columbia University Recruiting
New York, New York, United States, 10032
Contact: Helen Mejia-Santana    877-305-2438    research@corepdstudy.org   
United States, Pennsylvania
University of Pennsylvania Active, not recruiting
Philadelphia, Pennsylvania, United States, 19104
United States, Rhode Island
Neuro Health Active, not recruiting
Warwick, Rhode Island, United States, 02886
United States, Tennessee
University of Tennessee Health Science Center Active, not recruiting
Memphis, Tennessee, United States, 38136
United States, Wisconsin
Marshfield Clinic Active, not recruiting
Marshfield, Wisconsin, United States, 54449
Sponsors and Collaborators
Columbia University
Investigators
Principal Investigator: Karen Marder, M.D., M.PH. Columbia University
  More Information

No publications provided

Responsible Party: Columbia University
ClinicalTrials.gov Identifier: NCT00104585     History of Changes
Other Study ID Numbers: AAAA5609, R01NS036630
Study First Received: March 1, 2005
Last Updated: January 18, 2012
Health Authority: United States: Federal Government

Keywords provided by Columbia University:
Parkinson's disease
PD
gene
environment
early-onset Parkinson's disease

Additional relevant MeSH terms:
Parkinson Disease
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Movement Disorders
Nervous System Diseases
Neurodegenerative Diseases
Parkinsonian Disorders

ClinicalTrials.gov processed this record on October 23, 2014