Osteoarthritis: Weakness From Inflammation
The purpose of this study is to understand the factors that lead to muscle weakness with arthritis and aging.
|Study Design:||Observational Model: Cohort
Time Perspective: Cross-Sectional
|Official Title:||Weakness From Inflammation: A Basis of Disability From Knee Osteoarthritis|
Synovial fluid and tissue blood serum muscle biopsy
|Study Start Date:||April 2001|
|Study Completion Date:||May 2009|
|Primary Completion Date:||May 2009 (Final data collection date for primary outcome measure)|
Participants with symptomatic knee osteoarthritis
Participants without symptomatic knee osteoarthritis, age-matched as controls
Through this study, we hope to learn about the natural history of knee osteoarthritis and the disability that arises from it. We hope to better understand why people with knee osteoarthritis develop difficulty with mobility (e.g. walking, standing) in hopes of finding a cure.
This study requires 1 four-hour visit to Harbor Hospital. The visit involves a physical exam, a DEXA bone density scan, blood and urine testing, knee x-rays, strength testing and a surface electromyography (EMG). Samples of muscle, joint fluid and joint tissue will be collected during your planned surgery.
Participation in this study is entirely voluntary.
|United States, Maryland|
|Baltimore, Maryland, United States, 21225|
|Principal Investigator:||Shari Ling, MD||NIA, Johns Hopkins Medical Institution Divisions of Rheumatology, Gerontology, and Geriatrics|