Improved Language Acquisition With Levodopa
The purpose of this study is to determine whether the non-daily administration of levodopa is effective in boosting semantic language acquisition in healthy subjects.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Primary Purpose: Treatment
|Official Title:||Improved Language Acquisition With Levodopa|
- Boost in language learning success through levodopa compared to placebo
- Stability of language learning success after one month
|Study Start Date:||March 2003|
|Study Completion Date:||August 2005|
|Primary Completion Date:||August 2005 (Final data collection date for primary outcome measure)|
Our prior work using a between-subject design shows that daily administration of d-amphetamine or the dopamine precursor levodopa over the course of five days markedly improves word learning success in healthy subjects. In this randomized, placebo-controlled, double-blind clinical trial, we probe whether the effect can be replicated using a within-subject design, with administration of levodopa and placebo on alternate days for a total period of 10 days.
The expected scientific results will strengthen the basis for transferring neuromodulatory interventions from the laboratory to stroke patients with language dysfunctions. Because of the heterogeneity of stroke patients, only a within-subject design can be used to probe the effects of pharmacological adjuncts to language therapy.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00103805
|Dept. of Neurology, University Hospital Muenster|
|Muenster, Nordrhein-Westfalen, Germany, 48129|
|Study Director:||Caterina Breitenstein, PhD||Dept. of Neurology, University of Muenster, Germany|
|Study Chair:||Stefan Knecht, MD||Dept. of Neurology, University of Muenster, Germany|