Effect of Phosphatidylcholine on Plasma Homocysteine in Healthy Volunteers
The purpose of this study is to determine whether supplementation with phosphatidylcholine lowers plasma homocysteine concentrations in healthy men.
Procedure: supplementation with phosphatidylcholine
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Primary Purpose: Prevention
|Official Title:||Effect of Choline Supplemented as Phosphatidylcholine on Post-Methionine Loading and Fasting Concentrations of Plasma Homocysteine in Healthy Volunteers|
- Concentrations of plasma homocysteine in the fasting state
- Concentrations of plasma homocysteine after a methionine load
- Lipid concentrations
- Liver enzymes
|Study Start Date:||May 2003|
|Estimated Study Completion Date:||July 2003|
A high homocysteine concentration is a potential risk for cardiovascular disease. Plasma homocysteine concentrations can be lowered through betaine supplementation. However, effects of choline supplementation, the precursor for betaine, on plasma homocysteine concentrations in healthy humans are unknown. If supplementation with choline or phosphatidylcholine, the form in which choline occurs in foods, lowers homocysteine concentrations, then extra intake of these compounds may lower cardiovascular disease risk in humans.
Comparison: We compared the effects of supplementation with phosphatidylcholine to the effects of a placebo on fasting and post-methionine concentrations of plasma homocysteine in healthy men.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00102232
|Wageningen Centre for Food Sciences|
|Wageningen, Netherlands, 6703 HD|
|TNO Nutrition and Food Research|
|Zeist, Netherlands, 3700 AJ|
|Study Chair:||Petra Verhoef, PhD||Wageningen Centre for Food Sciences|
|Principal Investigator:||Elizabeth J Brink, PhD||TNO Nutrition and Food Research|