Periodontal Ligament Stress Level and Tooth Movement

This study has been completed.
Sponsor:
Information provided by:
University of Alberta, Graduate Orthodontic Program
ClinicalTrials.gov Identifier:
NCT00099814
First received: December 21, 2004
Last updated: June 28, 2010
Last verified: June 2010
  Purpose

Orthodontic treatment requires application of force systems to individual teeth or groups of teeth, which results in a cellular response with periodontal ligament (PDL) and alveolar bone remodeling. The forces applied must be of sufficient magnitude and duration to exceed the normal physiologic threshold associated with daily oral function. Excessive force levels will result in areas of tissue necrosis with delayed tooth movement and increased risk of root resorption. Although orthodontic tooth movement is achieved in a large segment of the population, the optimum force level has not been defined. The optimum force for tooth movement depends on individual root geometry as well as biologic characteristics of surrounding tissue including bone density, periodontal thickness, and fluid dynamics.

Because experimental and clinical techniques are generally limited to known complex force systems, biomechanical modeling has become a necessity. Such models must be validated with well-controlled clinical studies that evaluate orthodontic tooth movement over an extended distance. The ultimate goal would be development of a computer simulation model to predict tooth movement in the clinical setting.

The primary objective of this study is to test controlled clinical data with a biomechanical model of the tooth and supporting tissues for distal movement of the human maxillary canine tooth (of known root geometry) in response to various 3D force systems that produce different levels of stress in the supporting tissues. Secondary objectives include evaluation of rate of bodily tooth canine movement with two known compressive stress levels (13 and 22 kPa), evaluation of three different reference systems to measure rate of tooth movement, and evaluation of an implant placed in the roof of the mouth (palatal implant) for orthodontic anchorage in adolescent patients.

The rate of translation (bodily) tooth movement of the maxillary canine tooth will be significantly greater with 22kPa compared to 13kPa compressive stress applied to the periodontal ligament, and this difference can be predicted by appropriate mathematical/numerical models of the tooth and supporting tissues.


Condition Intervention Phase
Malocclusion, Angle Class III
Procedure: Two different loop designs which deliver distinctive forces
Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Single Blind
Primary Purpose: Treatment
Official Title: Clinical/Numerical Study of the Effects of Periodontal Ligament Stress Level on the Rate Bodily Tooth Movement

Resource links provided by NLM:


Further study details as provided by University of Alberta, Graduate Orthodontic Program:

Primary Outcome Measures:
  • Rate of space closure

Estimated Enrollment: 20
Study Start Date: March 2004
Study Completion Date: November 2005
Primary Completion Date: November 2005 (Final data collection date for primary outcome measure)
  Show Detailed Description

  Eligibility

Ages Eligible for Study:   12 Years to 16 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Female adolescent (12-16 years old) orthodontic patients requiring upper first premolars extractions for overjet reduction.
  • Participants will be healthy and not taking any medications.
  • All participants will have healthy periodontal tissues and good oral hygiene.

Exclusion Criteria:

  • Patients with medical contraindication for placement of a palatal implant.
  • All candidates who admit to tobacco utilization will be excluded.
  • Patients requiring lower dental extractions will also be excluded.
  • Pregnant patients or patients planning pregnancy will be excluded.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00099814

Locations
Canada, Alberta
Orthodontic Clinic - Department of Dentistry - University of Alberta
Edmonton, Alberta, Canada, T6G 2N8
Sponsors and Collaborators
University of Alberta, Graduate Orthodontic Program
  More Information

No publications provided

Responsible Party: Joanne Lafrance, research assistant, University of Alberta, Graduate Orthodontic Program
ClinicalTrials.gov Identifier: NCT00099814     History of Changes
Other Study ID Numbers: GOP-UA-CT-01
Study First Received: December 21, 2004
Last Updated: June 28, 2010
Health Authority: Canada: Health Canada

Keywords provided by University of Alberta, Graduate Orthodontic Program:
tooth movement
orthodontics
force
humans
clinical trial

Additional relevant MeSH terms:
Malocclusion
Malocclusion, Angle Class III
Tooth Diseases
Stomatognathic Diseases

ClinicalTrials.gov processed this record on April 22, 2014