CALERIE (PBRC, Baton Rouge) - Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy
This study is one of three CALERIE trials that test the hypothesis that a reduced calorie, nutritionally sound diet improves biomarkers of aging and prevents some age-related chronic diseases such as cancer, diabetes, and cardiovascular disease. The three sites that are participating in the CALERIE trial represent a diversity of subject populations and interventional strategies.
Behavioral: Caloric Restriction (CR)
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind
Primary Purpose: Prevention
|Official Title:||Metabolic Adaptations to Six Month Caloric Restriction|
|Study Start Date:||March 2002|
|Study Completion Date:||May 2006|
|Primary Completion Date:||May 2006 (Final data collection date for primary outcome measure)|
This study tests whether chronic caloric restriction improves risk factors of longevity in humans as it is known to do in animals, by measuring a variety of factors dealing with metabolism and oxidative stress, through physical evaluations and laboratory tests.
Participants will receive dietary counseling and free medical evaluations. In addition, each volunteer will be asked to do one of the following:
- Follow a reduced calorie diet
- Follow a reduced calorie diet using a liquid diet
- Increase physical activity while on a reduced calorie diet
- Follow a standard diet.
Three separate five-day inpatient stays are required.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00099151
|United States, Louisiana|
|Pennington Biomedical Research Center, 6400 Perkins Road|
|Baton Rouge, Louisiana, United States, 70808|
|Principal Investigator:||Eric Ravussin, Ph.D.||Pennington Biomedical Research Center|
|Principal Investigator:||Donald Williamson, Ph.D.||Pennington Biomedical Research Center|