Genetics of Fibromyalgia
Recruitment status was Active, not recruiting
The Fibromyalgia Family Study identifies and collects blood samples from families with two or more members affected with Fibromyalgia Syndrome (FMS). The primary goal of the study is to identify genes that predispose people to FMS and/or symptoms related to FMS; identifying these genes may lead to a better understanding of the disease and more effective treatments.
Irritable Bowel Syndrome
Chronic Fatigue Syndrome
|Study Design:||Observational Model: Family-Based
Time Perspective: Retrospective
|Official Title:||Fibromyalgia Family Study Registry|
DNA, whole blood
|Study Start Date:||September 1999|
FMS predominantly affects women and is characterized by chronic widespread musculoskeletal pain, fatigue, sleep disturbance, and multiple tender points on physical examination. The pathophysiological mechanisms underlying FMS are not clearly understood, but neuroendocrine factors seem to be of major importance. Studies of familial association suggest that genetic factors play a role in FMS. This study will establish patterns of genetic linkage in families with FMS.
Participating family members will undergo a brief physical exam (including tender point exam), donate a blood sample, and complete a detailed questionnaire that includes experience with pain, fatigue, depression, bowel symptoms, headache, anxiety, and physical limitations. Measurements of serum serotonin and related compounds will also be obtained. To detect genetic factors, a genome-wide linkage scan using 405 microsatellite markers will be performed.
|United States, Illinois|
|University of Illinois at Peoria|
|Peoria, Illinois, United States, 60612|
|United States, Ohio|
|University of Cincinnati|
|Cincinnati, Ohio, United States, 45221|
|Case Western Reserve University|
|Cleveland, Ohio, United States, 44109|
|United States, Texas|
|University of Texas Health Sciences Center|
|San Antonio, Texas, United States, 78229|
|Study Chair:||Sudha Iyengar, PhD||Case Western Reserve University|