Optical Coherence Tomography Comparative Study

This study has been completed.
Sponsor:
Information provided by:
National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:
NCT00069199
First received: September 17, 2003
Last updated: March 3, 2008
Last verified: August 2005
  Purpose

This study, conducted at the NIH Clinical Center and the University of Wisconsin University, will compare measurements obtained using older and newer models of a machine called an optical coherence tomography (OCT) scanner. This instrument uses a beam of light to measure the thickness of the retina, the light-sensitive inner lining of the back of the eye. OCT measurements will be done in multicenter clinical trials of new treatments for disorders that cause vision loss, such as macular edema. Because some centers in these studies will use the older OCT model and some the newer one, it is necessary to determine whether the two models give comparable results.

People 18 years of age and older in the following categories may be eligible for this study:

  • People with diabetes, with or without macular edema;
  • People with other retinal disease, such as uveitis or vein occlusion in the retina;
  • People with no history of eye disease who have a normal retina.

Participants will have the following tests and procedures:

  • Eye examination to assess vision and eye pressure and to evaluate the retina. The pupils are dilated with drops for this examination.
  • Stereoscopic color fundus photography to examine the back of the eye. Eye drops are used to enlarge the size of the pupils to allow for a through examination and photographs of the eye using a special camera that flashes a bright light into the eye.
  • OCT to measure retinal thickness. For this procedure, the subject sits in front of a small screen and looks at a target in the center of the screen while a dim red light moves across the subject's retina. This test is done first with one model of the OCT scanner, then the other. Finally, the test is repeated in both eyes with whichever model was used first.

Patients who are being treated for macular edema will repeat the same tests at their 3-month visits.


Condition
Retinal Disease
Healthy

Study Type: Observational
Official Title: Optical Coherence Tomography Comparative Study

Resource links provided by NLM:


Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment: 120
Study Start Date: September 2003
Estimated Study Completion Date: August 2005
Detailed Description:

The use of the Optical Coherence Tomography (OCT) has increased markedly over the recent years for clinical research. It is a promising new method for imaging the retina, measuring its thickness, and displaying some features of this structure. It is useful in assessing several eye diseases, including macular edema from various causes and abnormalities of the vitreoretinal interface. There is a broad clinical consensus that OCT is superior to stereoscopic color fundus photography, fluorescein angiography, and clinical biomicroscopic examination in measuring retinal thickness and is capable of documenting fairly small changes in thickness. OCT is becoming an important part of clinical trials of new treatments for macular edema. A number of models of the OCT device are commercially available, models 1, 2, and 3. A number of models of OCT have been used in clinical centers involved in such clinical research. Comparisons of these models 2 and 3 as well as the reproducibility of these measurements have not been conducted. The main research questions to be answered in this protocol are the following, in patients with normal retina, diabetic macular edema, macular edema from other causes, or other vitreoretinal abnormalities:

  1. Is the standard deviation of the differences of sequential measurements of retinal thickness in normal retinas using OCT 3 similar to those measured with the OCT 2?
  2. Are there systematic differences between thickness measurements using OCT 2 and OCT 3 in the same eyes?
  3. Are there differences in the ability of each machine to image abnormalities within the vitreoretinal interface?
  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

INCLUSION CRITERIA:

  1. Patient must understand and sign the informed consent.
  2. Patient must be at least 18 years of age.
  3. Pupillary dilation to at least 6 mm must be possible.
  4. Ocular media must be sufficiently clear to allow for quality images.

EXCLUSION CRITERIA:

1. Any condition such as corneal opacifiation that precludes adequate slit lamp examination and photography of the fundus.

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00069199

Locations
United States, Maryland
National Eye Institute (NEI)
Bethesda, Maryland, United States, 20892
Sponsors and Collaborators
  More Information

Publications:
ClinicalTrials.gov Identifier: NCT00069199     History of Changes
Other Study ID Numbers: 030294, 03-EI-0294
Study First Received: September 17, 2003
Last Updated: March 3, 2008
Health Authority: United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):
Reproducibility
Macular Edema
OCT2
OCT3
Retina

Additional relevant MeSH terms:
Retinal Diseases
Eye Diseases

ClinicalTrials.gov processed this record on July 26, 2014