Alzheimer's Disease Genetics Study

This study is currently recruiting participants. (see Contacts and Locations)
Verified April 2013 by Indiana University
Sponsor:
Collaborator:
Information provided by (Responsible Party):
Indiana University
ClinicalTrials.gov Identifier:
NCT00064870
First received: July 14, 2003
Last updated: April 3, 2013
Last verified: April 2013
  Purpose

The purpose of the Alzheimer's Disease Genetics Study is to identify the genes that are responsible for causing Alzheimer's Disease (AD). One of the ways in which the risk factor genes for late onset AD can be investigated is by identifying and collecting genetic material from families with multiple members diagnosed with AD or dementia.


Condition
Alzheimer Disease
Late Onset Alzheimer Disease
Dementia

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Alzheimer's Disease Genetics Study

Resource links provided by NLM:


Further study details as provided by Indiana University:

Biospecimen Retention:   Samples With DNA

blood samples


Estimated Enrollment: 3000
Study Start Date: June 2002
Estimated Study Completion Date: June 2016
Estimated Primary Completion Date: June 2016 (Final data collection date for primary outcome measure)
Detailed Description:

The purpose of the Alzheimer's Disease Genetics Study is to help identify the genes that may be responsible for causing Alzheimer's Disease (AD) by collecting genetic material from families with multiple members diagnosed with AD. Qualifying families will have two living blood-related individuals who have been diagnosed with or are showing symptoms of AD or dementia. Local study sites are located all over the United States, and arrangements may be made for eligible families who do not live near a participating site. The biological samples and data from these families will be made available to qualified researchers, who must sign a Materials Transfer Agreement (MTA) in order to protect the privacy rights of study participants before receiving DNA and data.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Families with two or more members with Alzheimer's disease or dementia

Criteria

Inclusion Criteria:

  • Two living family members diagnosed with AD or other dementia with any age of onset
  • Biological samples available

    • Fresh blood, or
    • Immortalized lymphoblastic cell lines, or
    • 3-5 grams of frozen cerebral cortex; fixed samples are not accepted

Please note: this study does not include genetic counseling; because no personal identifying information such as name or date of birth is attached to samples, results of individual tests are not available to participants or family members.

Exclusion Criteria:

  • Does not meet inclusion criteria
  • Member of a family that was included in the National Institute of Mental Health AD Genetics Sib Pair collection
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00064870

Contacts
Contact: Study Coordinator 1-800-526-2839 alzstudy@iupui.edu

Locations
United States, Indiana
Participants are being recruited from all over the United States Recruiting
Nationwide, Indiana, United States
Contact: NCRAD Study Coordinator    800-526-2839    alzstudy@iupui.edu   
Sponsors and Collaborators
Indiana University
Investigators
Principal Investigator: Tatiana M. Foroud, PhD National Cell Repository for Alzheimer's Disease (NCRAD), Indiana University
  More Information

Additional Information:
No publications provided

Responsible Party: Indiana University
ClinicalTrials.gov Identifier: NCT00064870     History of Changes
Other Study ID Numbers: IA0042, U24AG021886, NIH grant U24 AG21886
Study First Received: July 14, 2003
Last Updated: April 3, 2013
Health Authority: United States: Federal Government

Keywords provided by Indiana University:
Alzheimer disease
Late Onset Alzheimer disease risk factor genes
Genetics
Initiative
Dementia

Additional relevant MeSH terms:
Alzheimer Disease
Dementia
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Tauopathies
Neurodegenerative Diseases
Delirium, Dementia, Amnestic, Cognitive Disorders
Mental Disorders

ClinicalTrials.gov processed this record on July 29, 2014