The Effect of Weight Loss and Exercise on Knee Osteoarthritis
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Purpose
This study will evaluate whether a program of weight loss and exercise can help individuals with knee osteoarthritis (OA).
| Condition | Intervention |
|---|---|
|
Osteoarthritis, Knee |
Behavioral: Behavioral weight control and lifestyle exercise |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Factorial Assignment Masking: Open Label Primary Purpose: Treatment |
| Official Title: | The Impact of Weight Loss and Exercise on Knee Osteoarthritis |
- Pain [ Time Frame: 4 months and 16 months ] [ Designated as safety issue: No ]
| Enrollment: | 160 |
| Study Start Date: | September 2002 |
| Study Completion Date: | April 2006 |
| Primary Completion Date: | April 2006 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Experimental: 1
16 weekly educational meetings
|
Behavioral: Behavioral weight control and lifestyle exercise
16 weekly educational meetings vs. waitlist control
|
|
No Intervention: 2
Wait list control
|
Detailed Description:
Knee OA is a major public health challenge affecting millions of people in the United States. Obesity is a primary target for intervention since it accounts for up to 30% of knee OA, exacerbates symptoms, and is associated with bilateral involvement and more rapid progression of the disease. While the American College of Rheumatology (ACR) Practice Guidelines recommend modest weight loss as symptomatic therapy, no published clinical trials have investigated the impact of weight loss on knee OA.
Physical activity has also been associated with pain reduction and increased mobility in individuals with knee OA and the ACR Practice Guidelines indicate that it should be included in treatment. Exercise may be especially helpful for overweight persons with knee OA as it is a potent predictor of weight loss maintenance. Though adherence to traditional exercise programs has been poor, adopting lifestyles in which exercise is accumulated throughout the day appears to be a promising new approach to physical activity. Lifestyle exercise may enhance exercise adherence by increasing options to be active and reducing time barriers. Episodic physical activity may also be preferable to continuous exercise by reducing pain and avoiding injury. The primary objective of this proposal is to evaluate the impact of weight loss and lifestyle exercise on knee osteoarthritis.
Participants will be randomly assigned to either a behavioral weight loss and exercise program or a delayed intervention group. Participants in the behavioral weight loss and exercise group will attend weekly group meetings at the Johns Hopkins Bayview Medical Center for 16 weeks. Group meetings last about 1 hour and are led by health care professionals. Participants will be taught how to lose weight and keep weight off by changing what they eat and evaluating their lifestyle. Participants will be instructed on a safe and effective diet plan (1200 calories/day for women; 1500 calories/day for men) and will be asked to increase their physical activity to about 30 minutes per day of brisk walking, most days of the week. After the 16-week program, groups will continue to meet every three months for 1 year to help sustain lifestyle changes.
The delayed intervention group will receive the program described above after a 4-month waiting period.
The primary outcome measure will be knee pain. Secondary measures include physical disability, quality of life, performance measures, and long-term adherence to behavior change.
Eligibility| Ages Eligible for Study: | 19 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria
- Knee arthritis
- Pain on > 50 % of days in the month in one or both knees
- Difficulty with activities of daily living due to knee pain
- X-ray documenting knee OA within 1 year prior to study entry
- 15 lbs to 50 lbs overweight
Exclusion Criteria
- Significant cardiac, pulmonary, renal, or hepatic disease
- Major psychiatric disease
- ACR functional class IV
- Structured exercise more than once per week for 20 minutes or longer during the 3 months prior to study entry
- Anticipates moving from the area within 18 months of study entry
- Anticipates undergoing knee surgery within 1 year of study entry
- Weight loss of more than 5 kg (11 lbs) in 3 months prior to study entry
- Anorexiant or other medications known to affect metabolism
- Current or planned pregnancy
Contacts and Locations| United States, Maryland | |
| Johns Hopkins Bayview Medical Center | |
| Baltimore, Maryland, United States, 21224 | |
| Principal Investigator: | Susan J. Bartlett, MD | Johns Hopkins University |
More Information
Additional Information:
No publications provided
| Responsible Party: | Susan Bartlett, Associate Professor of Medicine, Johns Hopkins University |
| ClinicalTrials.gov Identifier: | NCT00061490 History of Changes |
| Other Study ID Numbers: | K23 AR002160, NIAMS-080 |
| Study First Received: | May 28, 2003 |
| Last Updated: | February 29, 2008 |
| Health Authority: | United States: Institutional Review Board United States: Federal Government |
Keywords provided by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS):
|
Osteoarthritis Arthritis Weight Loss |
Additional relevant MeSH terms:
|
Osteoarthritis Weight Loss Osteoarthritis, Knee Arthritis Joint Diseases |
Musculoskeletal Diseases Rheumatic Diseases Body Weight Changes Body Weight Signs and Symptoms |
ClinicalTrials.gov processed this record on May 22, 2013