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Familial Aggregation of Barrett's Esophagus

The recruitment status of this study is unknown because the information has not been verified recently.
Verified March 2010 by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
Recruitment status was  Active, not recruiting
Sponsor:
Information provided by:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
ClinicalTrials.gov Identifier:
NCT00058877
First received: April 14, 2003
Last updated: March 17, 2010
Last verified: March 2010
History of Changes
  Purpose

This research study is trying to determine whether Barrett's esophagus and associated esophageal cancers, specifically esophageal adenocarcinoma are inherited in certain families. Persons who are affected with Barrett's esophagus or esophageal cancer (adenocarcinoma type) are asked to complete a questionnaire that determines their habits and asks a detailed family history. Family members of patients seen at University Hospitals of Cleveland are also being recruited for screening tests of their esophagus. The investigators plan to eventually screen family members at all participating institutions. This research will eventually lead to the identification of inherited genetic changes that cause Barrett's esophagus and esophageal cancer. It will help the investigators develop better methods for preventing or identifying esophageal cancer at an early curable stage.


Condition
Barrett's Esophagus
Esophageal Neoplasm

Study Type: Observational
Official Title: Familial Aggregation of Barrett's Esophagus

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK):

Estimated Enrollment: 650
  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Eligible cases will be defined as those patients and their family members who meet the following criteria:

  • Barrett's esophagus confirmed by review of pathology and endoscopy report or adenocarcinoma of the esophagus or family members of person with Barrett's esophagus or adenocarcinoma of the esophagus.
  • Male or female age 18 or older at time of enrollment or male or female less than 18 years of age at time of enrollment with parental consent.
  • Ability to give informed consent, if patient is age 18 or older.
  • No history of radiation to the chest or abdomen.
  • No history of chemotherapy in the year preceding the initial diagnosis of Barrett's esophagus or esophageal adenocarcinoma.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00058877

Locations
United States, Ohio
University Hospitals of Cleveland
Cleveland, Ohio, United States, 44106-8066
Cleveland Clinic Foundation
Cleveland, Ohio, United States
Ohio State University
Columbus, Ohio, United States
United States, Tennessee
Vanderbilt University Medical Center
Nashville, Tennessee, United States
Sponsors and Collaborators
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00058877     History of Changes
Other Study ID Numbers: FABE
Study First Received: April 14, 2003
Last Updated: March 17, 2010
Health Authority: United States: Federal Government

Keywords provided by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK):
Barrett's
Esophagus

Additional relevant MeSH terms:
Barrett Esophagus
Neoplasms
Esophageal Diseases
Esophageal Neoplasms
Digestive System Abnormalities
Digestive System Diseases
 Gastrointestinal Diseases
Gastrointestinal Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Head and Neck Neoplasms

ClinicalTrials.gov processed this record on June 17, 2013