Therapy for Depression With Co-occurring Panic or Anxiety Symptoms

This study has been completed.
Sponsor:
Information provided by:
University of Pittsburgh
ClinicalTrials.gov Identifier:
NCT00051207
First received: January 7, 2003
Last updated: June 21, 2013
Last verified: December 2007
  Purpose

This 6-month study, with a 3-month follow up period, will compare the effectiveness of new and traditional psychotherapies for depression with panic or anxiety symptoms.


Condition Intervention Phase
Depression
Anxiety Disorders
Panic Disorder
Behavioral: Interpersonal Psychotherapy (IPT)
Behavioral: IPT for Depression with Co-occurring Panic and Anxiety Symptoms (IPT-PS)
Phase 1
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Interpersonal Psychotherapy for Depression With Co-occurring Panic and Anxiety Symptoms (IPT-PS)

Resource links provided by NLM:


Further study details as provided by University of Pittsburgh:

Estimated Enrollment: 36
Study Start Date: November 2002
Study Completion Date: August 2005
Detailed Description:

Many depressed patients also experience significant symptoms of panic or anxiety. This study will compare the effectiveness of a new therapy called interpersonal psychotherapy for depression with panic or anxiety symptoms (IPT-PS) with that of traditional interpersonal psychotherapy for depression (IPT).

Participants are randomly assigned to receive up to 24 weeks of treatment with either IPT-PS or traditional IPT. Improvements in interpersonal functioning, quality of life, and symptoms of depression and anxiety will be assessed at the end of therapy and at a 3-month follow-up.

  Eligibility

Ages Eligible for Study:   18 Years to 60 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • DSM-IV diagnosis of major depression with co-existing panic or anxiety symptoms.

Exclusion Criteria:

  • History of manic episode(s). Patients who have had hypomanic episodes in the past will be accepted into the study, provided they meet other admission criteria and are not presenting in a current hypomanic or mixed episode.
  • History of schizophrenia or schizoaffective disorder.
  • Organic affective syndrome.
  • Unspecified functional psychosis.
  • Anorexia nervosa or bulimia nervosa. Patients meeting criteria for an eating disorder not otherwise specified will not be excluded.
  • Chronic drug or alcohol abuse/dependence within the past 2 years. Patients with abuse related to episodes will not be excluded.
  • DSM-IV criteria for borderline or antisocial personality disorder. Patients who meet criteria for other Axis II disorders will not be excluded.
  • Inpatient treatment due to suicide risk or psychotic symptoms.
  • Index episode secondary to the effect of medically prescribed drugs.
  • Significant or untreated medical illness, including cardiovascular disorder, renal or liver disease, epilepsy, untreated hypertension, or unstabilized endocrine disease.
  • Medical illness that would interfere with the best treatment strategy for the potential participant.
  • Current treatment with an antidepressant. Patients on a stable dose of anxiolytics for at least 3 months prior to study participation who are able to maintain this dosage throughout the study will not be excluded.
  • Pregnant and breast-feeding women will be accepted into the study, but will not be prescribed adjunctive medications.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00051207

Locations
United States, Pennsylvania
Western Psychiatric Institute and Clinic - Depression and Manic Depression Program
Pittsburgh, Pennsylvania, United States, 15213
Sponsors and Collaborators
University of Pittsburgh
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00051207     History of Changes
Other Study ID Numbers: R21 MH61948, DSIR AT-AS
Study First Received: January 7, 2003
Last Updated: June 21, 2013
Health Authority: United States: Federal Government

Keywords provided by University of Pittsburgh:
Mood Disorders
Psychotherapy
Comorbidity

Additional relevant MeSH terms:
Anxiety Disorders
Depression
Depressive Disorder
Panic Disorder
Mental Disorders
Behavioral Symptoms
Mood Disorders

ClinicalTrials.gov processed this record on April 15, 2014