Therapy for Depression With Co-occurring Panic or Anxiety Symptoms

This study has been completed.
Sponsor:
Information provided by:
University of Pittsburgh
ClinicalTrials.gov Identifier:
NCT00051207
First received: January 7, 2003
Last updated: June 21, 2013
Last verified: December 2007
  Purpose

This 6-month study, with a 3-month follow up period, will compare the effectiveness of new and traditional psychotherapies for depression with panic or anxiety symptoms.


Condition Intervention Phase
Depression
Anxiety Disorders
Panic Disorder
Behavioral: Interpersonal Psychotherapy (IPT)
Behavioral: IPT for Depression with Co-occurring Panic and Anxiety Symptoms (IPT-PS)
Phase 1
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Interpersonal Psychotherapy for Depression With Co-occurring Panic and Anxiety Symptoms (IPT-PS)

Resource links provided by NLM:


Further study details as provided by University of Pittsburgh:

Estimated Enrollment: 36
Study Start Date: November 2002
Study Completion Date: August 2005
Detailed Description:

Many depressed patients also experience significant symptoms of panic or anxiety. This study will compare the effectiveness of a new therapy called interpersonal psychotherapy for depression with panic or anxiety symptoms (IPT-PS) with that of traditional interpersonal psychotherapy for depression (IPT).

Participants are randomly assigned to receive up to 24 weeks of treatment with either IPT-PS or traditional IPT. Improvements in interpersonal functioning, quality of life, and symptoms of depression and anxiety will be assessed at the end of therapy and at a 3-month follow-up.

  Eligibility

Ages Eligible for Study:   18 Years to 60 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • DSM-IV diagnosis of major depression with co-existing panic or anxiety symptoms.

Exclusion Criteria:

  • History of manic episode(s). Patients who have had hypomanic episodes in the past will be accepted into the study, provided they meet other admission criteria and are not presenting in a current hypomanic or mixed episode.
  • History of schizophrenia or schizoaffective disorder.
  • Organic affective syndrome.
  • Unspecified functional psychosis.
  • Anorexia nervosa or bulimia nervosa. Patients meeting criteria for an eating disorder not otherwise specified will not be excluded.
  • Chronic drug or alcohol abuse/dependence within the past 2 years. Patients with abuse related to episodes will not be excluded.
  • DSM-IV criteria for borderline or antisocial personality disorder. Patients who meet criteria for other Axis II disorders will not be excluded.
  • Inpatient treatment due to suicide risk or psychotic symptoms.
  • Index episode secondary to the effect of medically prescribed drugs.
  • Significant or untreated medical illness, including cardiovascular disorder, renal or liver disease, epilepsy, untreated hypertension, or unstabilized endocrine disease.
  • Medical illness that would interfere with the best treatment strategy for the potential participant.
  • Current treatment with an antidepressant. Patients on a stable dose of anxiolytics for at least 3 months prior to study participation who are able to maintain this dosage throughout the study will not be excluded.
  • Pregnant and breast-feeding women will be accepted into the study, but will not be prescribed adjunctive medications.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00051207

Locations
United States, Pennsylvania
Western Psychiatric Institute and Clinic - Depression and Manic Depression Program
Pittsburgh, Pennsylvania, United States, 15213
Sponsors and Collaborators
University of Pittsburgh
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00051207     History of Changes
Other Study ID Numbers: R21 MH61948, DSIR AT-AS
Study First Received: January 7, 2003
Last Updated: June 21, 2013
Health Authority: United States: Federal Government

Keywords provided by University of Pittsburgh:
Mood Disorders
Psychotherapy
Comorbidity

Additional relevant MeSH terms:
Anxiety Disorders
Depression
Depressive Disorder
Panic Disorder
Mental Disorders
Behavioral Symptoms
Mood Disorders

ClinicalTrials.gov processed this record on August 28, 2014