Health Effects of Early-Life Exposure to Urban Pollutants in Minority Children
A molecular epidemiologic study of African American and Hispanic mothers and newborns to investigate the role of common urban pollutants on procarcinogenic and developmental damage.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Health Effects of Early-Life Exposure to Urban Pollutants in Minority Children|
- Neurobehavioral development [ Time Frame: 1 to 12 years ] [ Designated as safety issue: No ]
- Asthma [ Time Frame: 2-12 years ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
We collected maternal urine during the third trimester of pregnancy, maternal blood at delivery, umbilical cord blood, meconium, blood and urine from the child at ages 24, 36, and 60 months.
|Study Start Date:||August 1997|
|Study Completion Date:||May 2013|
|Primary Completion Date:||May 2013 (Final data collection date for primary outcome measure)|
The major objective of the proposed research is to study the impact of early-life exposures to common urban pollutants on neurobehavioral development and asthma in a sample of children living in three low-income, minority communities of New York City (Central Harlem, Washington Heights and the South Bronx). Using a molecular epidemiologic approach with monitoring, biomarkers, and clinical assessments at serial time points, we will extend our study of African-American and Latina urban mothers and children in order to follow the cohort through child age 11 years to assess the longer-term impact of exposures on child health and developmental outcomes.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00043498
|United States, New York|
|Columbia University, 722 W 168th St, 12th Floor|
|New York, New York, United States, 10032|
|Principal Investigator:||Frederica P Perera, DrPH, PhD||Columbia University|