Healthy Aging and Memory Study

This study has been completed.
Sponsor:
Information provided by:
National Institute on Aging (NIA)
ClinicalTrials.gov Identifier:
NCT00034567
First received: April 30, 2002
Last updated: September 14, 2007
Last verified: September 2007
  Purpose

This project will focus on the development and testing of efficient, cost effective measures that are specifically designed for use in Alzheimer's Disease (AD) primary prevention trials.


Condition
Alzheimer Disease

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Longitudinal
Official Title: Alzheimer's Disease Prevention Instrument Protocol

Resource links provided by NLM:


Further study details as provided by National Institute on Aging (NIA):

Estimated Enrollment: 650
Detailed Description:

This project will focus on the development and testing of efficient, cost effective measures that are specifically designed for use in AD primary prevention trials. The new or improved measures that have been developed will then be evaluated in 650 nondemented subjects enrolled in a simulated Alzheimer's disease prevention trial. Once enrolled, subjects will be followed for four years with annual clinical evaluations and interim six-month phone calls.

  Eligibility

Ages Eligible for Study:   75 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • 75 years or older.
  • Fluent in English or Spanish.
  • Stable medical condition for four weeks prior to screening visit.
  • Stable medications for four weeks prior to screening visit.
  • Either cognitively normal, or mild cognitive impairment. If MCI, the subject's CDR at screening have a global score of 0.5.
  • mMMSE score greater than 88 for subjects with at least 8 years education, or greater than 80 for subjects with less than 8 years education, and FCSRT total free plus cued recall score greater than 44 with 3 learning trials.
  • Willing to participate in four to five year follow-up study.
  • Willing to identify person who can serve as informant.
  • At least six years education or work history sufficient to exclude mental retardation

Exclusion Criteria:

  • Meets DSM IV criteria for dementia
  • History of clinically significant medical illness that would interfere with participation in trial, including active malignancy, myocardial infarction, or cerebrovascular accident within the past year
  • Alcohol or substance abuse and/or active major psychiatric disorders
  • Concurrent participation in a clinical drug trial
  • History of mental retardation
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00034567

  Show 39 Study Locations
Sponsors and Collaborators
Investigators
Study Director: Steven H. Ferris, PhD New York University School of Medicine
  More Information

Additional Information:
Publications:

ClinicalTrials.gov Identifier: NCT00034567     History of Changes
Other Study ID Numbers: IA0032
Study First Received: April 30, 2002
Last Updated: September 14, 2007
Health Authority: United States: Federal Government

Keywords provided by National Institute on Aging (NIA):
Prevention

Additional relevant MeSH terms:
Alzheimer Disease
Dementia
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Tauopathies
Neurodegenerative Diseases
Delirium, Dementia, Amnestic, Cognitive Disorders
Mental Disorders

ClinicalTrials.gov processed this record on September 29, 2014